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Enhanced transformation of antibiotic resistance genes: a new environmental risk of tire wear particles and leachates
Plant Diversity
2026
Xiaomei Liu,
Mengzhen Yin,
Chuanda Zhou,
Xinyue Xu,
Jiaqi Yan,
Yajun Xu,
Shakeel Ahmad,
Jingchun TANG
Summary
Researchers found that tire wear particles (TWPs) and their leachate can significantly enhance the transfer of antibiotic resistance genes (ARGs) into bacteria, with leachate increasing transformation frequency up to 13-fold compared to controls. The leachate promoted ARG uptake by inducing oxidative stress and increasing membrane permeability, while the particles themselves had an opposing inhibitory effect, revealing a complex dual mechanism by which TWPs may accelerate the spread of antibiotic resistance in the environment.
Polymers