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Postbiotic from Bifidobacteria-Fermented Tomato Juice Alleviates Lipid Metabolism Disorders Caused by Microplastics
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This mini-review summarized progress in PETase enzyme research for PET plastic degradation, covering enzyme discovery, engineering improvements, and prospects for industrial application. The review highlights advances in thermostable PETase variants and assesses the remaining barriers to commercially viable enzymatic PET recycling.
Microplastics (MPs) are widely distributed in the environment and can enter the human body via drinking water or inhaling MPs dust. Accumulation of MPs can lead to various health issues, including damage to the colonic mucosal barrier and liver damage. Consuming postbiotics may offer benefits such as reducing inflammation and enhancing immune response. However, there is limited research on whether the intake of postbiotics can mitigate the damage caused by MPs. Therefore, this study utilized a postbiotic derived from fermented tomato juice with a combination of Bifidobacterium animalis subsp. lactis H22B621, Bifidobacterium bifidum H22B664, and Bifidobacterium longum F58-9 to investigate their protective effects against MPs exposure in mice. Results showed that gavage with postbiotic from Bifidobacteria-fermented tomato juice could alleviate triglyceride (TG) accumulation in the liver by decreasing Coriobacteriaceae bacterium abundance and regulating octanoic acid synthesis. Meanwhile, after postbiotic gavage, beneficial bacteria in the gut increased, such as Lachnospiraceae bacterium A2 and Duncaniella freteri. In addition, serum alanine aminotransferase (ALT) levels significantly decreased, indicating that postbiotics could alleviate liver damage. Postbiotic treatment also alleviated colon barrier injury. This research provides evidence for the protective effect of postbiotics against the damage caused by MPs, further elucidates their mechanisms, and offers new perspectives on the development and utilization of probiotics.
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Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice
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Researchers found that mice exposed to PET microplastics (the type commonly found in plastic bottles) over 17 weeks developed liver damage, including fat buildup, oxidative stress, and cell death. The study revealed that the damage was driven by changes in gut bacteria that altered lipid metabolism, and when researchers depleted the gut bacteria, the liver damage was reduced. This suggests the gut microbiome plays a key role in how microplastics cause harm to internal organs.
Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
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Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: Insights from oral exposure studies
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Mice that drank water containing tiny acrylic-type plastic particles (PMMA) for eight weeks developed liver damage, gut microbiome changes, and disrupted fat metabolism. The plastic particles accumulated in the liver and colon, triggering oxidative stress and activating pathways that increased cholesterol production. This study suggests that chronic exposure to even common plastic types through drinking water could harm liver health by disrupting the gut-liver connection.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
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Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
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Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.