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The Biological Clock of Entropy: Quantifying "Time-to-Collapse" in Nanoplastic-Stressed Tissues

Zenodo (CERN European Organization for Nuclear Research) 2026
Peter Mikuláš, Peter Mikuláš

Summary

Scientists have developed a new way to predict how long it takes for tiny plastic particles (nanoplastics) to damage cells enough to potentially cause cancer. The research suggests that nanoplastics gradually wear down cellular "batteries" (mitochondria) over time, and by measuring this damage, researchers can estimate when healthy cells might turn cancerous. This could help us better understand the long-term health risks of plastic pollution in our environment and bodies.

How much time does a biological system have before physical stress turns into malignancy? This paper introduces a predictive framework for determining the "Remaining Energetic Life" (REL) of tissue. We argue that cancer is the final stage of a time-dependent erosion of cellular hardware. By calculating the ratio between nanoplastic-induced ion leakage and mitochondrial repair capacity, we can estimate the temporal window before a thermodynamic phase transition (oncogenesis) occurs.

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