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[Environmental pollutants and Alzheimer's disease].
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This review examined how environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, and microplastics contribute to Alzheimer's disease pathogenesis by promoting beta-amyloid accumulation, tau hyperphosphorylation, and neuroinflammation, suggesting that pollutant exposure is an underappreciated risk factor.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment. The main hypotheses about the pathogenesis of AD include the hypothesis of β-amyloid protein, the hypothesis of abnormal phosphorylation of Tau protein, and the hypothesis of neuroinflammation. In recent years, environmental pollutants have been considered as an important factor in causing neurological dysfunction. Common environmental pollutants include heavy metals, pesticides, polychlorinated biphenyls, microplastics, and air pollutants, all of which have been proven to have neurotoxicity. In this review, we not only discussed epidemiological and animal experimental studies that link environmental pollution with AD, but also summarized the mechanisms of action of relevant toxins, providing insights for studying the interrelationships between environmental pollutants and AD.
More Papers Like This
[Environmental pollutants and Alzheimer's disease].
AI summary Read the abstract
This review examines how common environmental pollutants — including heavy metals, pesticides, and microplastics — contribute to Alzheimer's disease risk by damaging neurons, triggering inflammation, and promoting the hallmark protein buildups (amyloid-beta and tau) seen in the disease. Microplastics are identified as an emerging neurotoxic pollutant alongside more established chemicals. The evidence adds to growing concern that everyday environmental exposures, not just genetics, play a meaningful role in driving dementia.
Environmental neurotoxicants as accelerators of brain ageing: exposomic mechanisms linking pollution to amyloidogenesis and Alzheimer's disease.
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This review summarizes existing research on how pollutants, including air pollution, heavy metals, pesticides, and micro- and nanoplastics, may enter the brain and contribute to processes linked to Alzheimer's disease, such as protein buildup and inflammation. The authors note that most evidence comes from lab and animal studies, with limited research so far in humans.
Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
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This review examines how environmental contaminants, including microplastics, may contribute to Alzheimer's disease risk. Along with air pollutants, toxic metals, and pesticides, plastics and microplastics are identified as potential risk factors that may promote brain inflammation and neurodegeneration. The review explores the molecular mechanisms behind these effects and suggests strategies to reduce the brain health impacts of environmental contaminants.
The Role of Emerging Environmental Contaminants on Alzheimer’s Disease
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This review examined the role of emerging environmental contaminants, including microplastics, in the development and progression of Alzheimer's disease. The authors discussed mechanisms including oxidative stress, neuroinflammation, and blood-brain barrier disruption as potential pathways linking environmental exposures to AD pathogenesis.
Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease
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This review pulls together existing research showing that pollution—including air pollution, heavy metals, pesticides, and even microplastics—may contribute to Alzheimer's disease by damaging the brain over decades, sometimes starting as early as childhood in people who grow up in heavily polluted areas. This matters because it suggests some Alzheimer's risk isn't just genetic or age-related, but tied to environmental exposures we can potentially reduce through personal choices and public policy, making prevention possible earlier in life than previously thought.
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