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Formulation, Development and Evaluation of Effervescent Tablet of Green Tea (Camellia sinensis).
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This study formulated, developed, and evaluated an effervescent tablet of green tea (Camellia sinensis), aiming to improve patient compliance and bioavailability for its multiple pharmacological benefits including antioxidant and anti-tumour properties. The formulation was optimized to provide a convenient and effective dosage form.
BACKGROUND: Camellia sinensis has an extensive variety of pharmacological properties, including neuroprotection, photo-aging resistance, stress resistance, antioxidant, anti-tumour, hypoglycemic, antibacterial, and antiviral effects tracing a good potential in addressing illness and preventing disease. Challenges with conventional dosage forms include patient incompatibility, improper dosing, the inclusion of microplastics, etc. Objective: The present work aims to deliver a novel formulation devoid of microplastics and with improved consumer compliance. METHODS: Wet granulation was used to formulate 500 mg Camellia sinensis effervescent tablets, with improved effervescent time and rapid release. Citric acid and sodium bicarbonate's impacts on disintegration time and pH were examined using a factorial design. Pre-compression variables were assessed for the granule mixture. Post-compression criteria were employed to assess effervescent tablets. The optimum formulation was selected using a central composite response surface and assessment criteria. RESULTS: The physicochemical characteristics of the developed formulations were significantly influenced by the independent factors. Low concentrations of sodium bicarbonate have positive impact on pH whereas high concentrations of sodium bicarbonate as well as citric acid enhance disintegration time. The design outcomes showed that the optimized effervescent tablets (F10) prepared with 697.5 mg and 448.38 mg of citric acid and sodium bicarbonate respectively had good physicochemical properties. CONCLUSION: In compliance with present quality standards, factorial design was efficiently utilized for the development of Camellia sinensis effervescent tablets. It was concluded that green tea effervescent tablet (F10) would function as a substitute for conventional green tea powder along with green tea bags as a means of administration.
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