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Meta Analysis ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 1 ? Systematic review or meta-analysis. Synthesizes findings across many studies. Strongest evidence. Detection Methods Environmental Sources Human Health Effects Nanoplastics Reproductive & Development Sign in to save

Micro- and nanoplastic effects on the reproduction of Daphnia spp. – a meta-analysis

Environmental Toxicology and Chemistry 2025
Ana L. Antonio Vital, Luca Liprandi, Christian Laforsch, Magdalena M. Mair

Summary

This meta-analysis pooled data from 369 measurements to assess how micro- and nanoplastics affect reproduction in Daphnia water fleas, a key species in freshwater ecosystems. The results showed that smaller particles, irregular shapes, and certain polymer types caused greater reproductive harm. Since Daphnia are a foundational species in freshwater food webs, their reproductive decline from plastic exposure could cascade through ecosystems that provide drinking water and food.

Body Systems
Models
Study Type Review

Several micro- and nanoplastic particle (MNP) traits, like polymer type, size, and shape, have been shown to influence MNP toxicity. However, the direction and strength of these moderating effects are often unclear, and generalizations from single studies are challenging to establish. Meta-analyses increase generalizability and derive more accurate and precise effect size estimates by combining measurements from published studies. We conducted a meta-analysis to investigate the effects of MNP exposure on the reproductive output of water fleas of the genus Daphnia by aggregating 369 data points from 64 studies. We show that daphnids exposed to MNP produce, on average, 13.6 fewer neonates, a reduction of 20.8% compared with the particle-free controls (control mean = 65.37 neonates). This effect is moderated by MNP concentration, exposure duration, experimental temperature, and size category, with microplastics eliciting a stronger negative effect than nanoplastic particles. Shape category, species, age, polymer type, size (micrometers), fluorescence, modification type, presence of surfactant, and dissolved organic matter did not influence effect sizes significantly. Based on the high residual heterogeneity in the data, we suggest that additional factors likely influence observed effects and discuss how better particle characterization could improve our understanding of the drivers of MNP toxicity.

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