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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Marine & Wildlife Sign in to save

Assessment of microplastic-sorbed contaminant bioavailability through analysis of biomarker gene expression in larval zebrafish

Marine Pollution Bulletin 2017 183 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Adil Bakir, Richard C. Thompson Adil Bakir, Victoria A. Sleight, Victoria A. Sleight, Victoria A. Sleight, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Adil Bakir, Adil Bakir, Adil Bakir, Theodore B. Henry, Richard C. Thompson Adil Bakir, Adil Bakir, Richard C. Thompson Adil Bakir, Adil Bakir, Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Theodore B. Henry, Theodore B. Henry, Adil Bakir, Adil Bakir, Adil Bakir, Adil Bakir, Adil Bakir, Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Theodore B. Henry, Adil Bakir, Theodore B. Henry, Theodore B. Henry, Theodore B. Henry, Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Theodore B. Henry, Richard C. Thompson Richard C. Thompson Adil Bakir, Richard C. Thompson Theodore B. Henry, Richard C. Thompson Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Theodore B. Henry, Richard C. Thompson Richard C. Thompson Theodore B. Henry, Adil Bakir, Richard C. Thompson Theodore B. Henry, Adil Bakir, Theodore B. Henry, Richard C. Thompson Theodore B. Henry, Adil Bakir, Richard C. Thompson Richard C. Thompson Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Richard C. Thompson Adil Bakir, Richard C. Thompson Theodore B. Henry, Theodore B. Henry, Theodore B. Henry, Richard C. Thompson Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Theodore B. Henry, Richard C. Thompson Adil Bakir, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Theodore B. Henry, Theodore B. Henry, Adil Bakir, Richard C. Thompson Richard C. Thompson Adil Bakir, Richard C. Thompson Adil Bakir, Adil Bakir, Theodore B. Henry, Adil Bakir, Richard C. Thompson Adil Bakir, Richard C. Thompson Victoria A. Sleight, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Adil Bakir, Theodore B. Henry, Richard C. Thompson Richard C. Thompson Victoria A. Sleight, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Theodore B. Henry, Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson Richard C. Thompson

Summary

Researchers examined whether contaminants sorbed to microplastics become bioavailable when ingested by larval zebrafish, using phenanthrene and ethinylestradiol as test chemicals. The study found that microplastics can alter the bioavailability of co-contaminants, as evidenced by changes in biomarker gene expression in the fish larvae.

Models
Zebrafish

Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here "co-contaminants") can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log<sub>10</sub>K<sub>ow</sub>=4.57; and 17α-ethinylestradiol (EE2), log<sub>10</sub>K<sub>ow</sub>=3.67] to MPs; and assess whether co-contaminant bioavailability was increased after MP settlement. Bioavailability was indicated by gene expression in larval zebrafish. Both Phe and EE2 sorbed to MPs, which reduced bioavailability by a maximum of 33% and 48% respectively. Sorption occurred, but was not consistent with predictions based on co-contaminant physicochemistry (Phe having higher log<sub>10</sub>K<sub>ow</sub> was expected to have higher sorption). Contaminated MPs settled to the bottom of the exposures did not lead to increased bioavailability of Phe or EE2. Phe was 48% more bioavailable than predicted by a linear sorption model, organism-based measurements therefore contribute unique insight into MP co-contaminant bioavailability.

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