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Inhibition of HDAC3 Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice In Vivo and In Vitro

Journal of Diabetes Research 2019 60 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Meng Jiang, Bo Zhao, Quan Yuan, Jiabao Hou, Jiabao Hou, Meng Jiang, Zhongyuan Xia Liying Zhan, Zhongyuan Xia Mei Li, Meng Jiang, Zhongyuan Xia Meng Jiang, Wenwei Gao, Lian Liu, Zhongyuan Xia

Summary

This study found that inhibiting the enzyme HDAC3 reduced brain injury caused by ischemia-reperfusion in diabetic mice by reducing oxidative stress and cell death. While not directly about microplastics, the findings contribute to understanding how environmental stressors may interact with diabetes-related neurological vulnerability.

Body Systems

Nervous

Models

Mouse

Study Type In vivo

These results suggested that the HDAC3 was involved in the pathological process of the complex disease of diabetic stroke. Suppression of HDAC3 exerted protective effects against cerebral I/R injury in diabetic state in vivo and in vitro via the modulation of oxidative stress, apoptosis, and autophagy, which might be mediated by the upregulation of Bmal1.

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