We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Developmental stage-dependent carrier effects of nanoplastics on PFOS bioaccumulation and toxicity in zebrafish: Insights from toxicokinetic-toxicodynamic perspective
AI summary Read the abstract
Researchers used a toxicokinetic-toxicodynamic framework to study how nanoplastics affect the accumulation and toxicity of the pollutant PFOS in zebrafish at different developmental stages. They found that nanoplastics reduced PFOS uptake in embryos, offering some protection, but significantly increased PFOS accumulation and toxic effects in larvae. The study highlights that nanoplastics can act as either toxicity mitigators or amplifiers depending on the organism's life stage.
The long-term coexistence of nanoplastics (NPs) and persistent pollutants like perfluorooctane sulfonate (PFOS) in aquatic ecosystems necessitates an understanding of their combined effects on organisms across different life stages. Here, a toxicokinetic-toxicodynamic (TK-TD) framework was employed to elucidate life stage-dependent mechanisms of NPs-PFOS interactions in zebrafish. At the embryonic stage (0-48 h), the presence of NPs reduced PFOS accumulation by decreasing its bioavailability, consequently mitigating hatching suppression relative to PFOS exposure alone. Conversely, at the larval stage (72-168 h), combined exposure significantly increased PFOS accumulation and exacerbated multilevel toxic effects, including oxidative stress, metabolic dysregulation, disruption of circadian/visual/nervous pathways, and ultimately behavioral deficits (e.g., abnormal swimming). Using the TK model, we quantified the bioaccumulation kinetics modulated by NPs in zebrafish during the embryonic and larval stages. The Bayesian benchmark dose (BBMD) model based on internal concentration indicated no significant alteration of the PFOS dose-response relationship by NPs, implying that the carrier effect of NPs was the primary mechanism driving life stage-specific outcomes. These findings highlight the necessity of investigating life stage-specific risks for NPs-contaminant co-exposure, where NPs transition from toxicity mitigators in embryos to toxicity amplifiers in larvae mediated by carrier effects, as quantified by the TK-TD perspective.
More Papers Like This
Contrasting effects of micro- and nanoplastics on accumulation and toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish embryo revealed by toxicokinetic-toxicodynamic model
AI summary Read the abstract
Researchers examined how microplastics and nanoplastics differently affect the accumulation and toxicity of the flame retardant TDCIPP in zebrafish embryos. The study found that while microplastics had minimal effect, nanoplastics significantly increased TDCIPP bioaccumulation and enhanced adverse effects on hatching, development, and survival, as validated by toxicokinetic and toxicodynamic modeling.
Quantifying the Amplification of Organophosphate Ester-Induced Visual Risk by Nanoplastics Considering Dual Mechanisms of Vector Effects and Efflux Inhibition
AI summary Read the abstract
Researchers quantified how nanoplastics amplify the visual toxicity of the flame retardant TDCIPP in zebrafish through two mechanisms: acting as a physical carrier that increases pollutant delivery to tissues, and inhibiting cellular efflux systems that normally expel toxins. They developed a quantitative model to predict the combined risk under realistic environmental conditions. The study reveals that nanoplastics can significantly worsen the harmful effects of co-occurring chemical contaminants through multiple biological pathways.
The role of nanoplastics on the toxicity of the herbicide phenmedipham, using Danio rerio embryos as model organisms
AI summary Read the abstract
Researchers found that polystyrene nanoplastics altered the toxicity of the herbicide phenmedipham to zebrafish embryos, with combined exposure producing different developmental effects than either contaminant alone, suggesting nanoplastics can modify pesticide bioavailability.
Sorption of PFOS onto polystyrene microplastics potentiates synergistic toxic effects during zebrafish embryogenesis and neurodevelopment
AI summary Read the abstract
Researchers found that polystyrene microplastics can absorb PFOS (a persistent industrial chemical) from water and deliver it to zebrafish embryos in a more concentrated form. The combination caused worse developmental problems than either pollutant alone, including delayed hatching, higher death rates, birth defects, and impaired brain development. This shows microplastics can act as carriers that intensify the toxic effects of other environmental chemicals.
Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)
AI summary Read the abstract
Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.