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Toxicity Risk of Microplastics and Nanoplastics to Environmental and Human Health
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Researchers exposed zebrafish embryos and human cell lines to microplastics and nanoplastics and observed uptake of particles along with toxicity including impaired embryo growth, cardiovascular effects in fish, and reduced energy production in human cells. The study demonstrates cross-species toxicity risks from plastic particle exposure.
This research studied the toxicity risks of microplastics and nanoplastics to environmental and human health. Plastic particles were observed to be taken up by zebrafish embryos and human cell lines and caused a variety of toxicity responses including effects on embryo growth and development and the cardiovascular system of fish, and reduced the energy production in human cells.
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Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
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This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Micro- and Nanoplastics Exposure and Effects on Embryonic Development and Larval Behavior of Zebrafish
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Researchers exposed zebrafish embryos to nanoplastics for three to five days and measured developmental and behavioral endpoints, finding that plastic accumulation in early development slowed yolk consumption and body growth on day two and increased locomotion while reducing body length by day six — supporting persistent developmental disruption from nanoplastic exposure.
Zebrafish: An emerging model to study microplastic and nanoplastic toxicity
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This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.
Toxic effects of environmental-relevant exposure to polyethylene terephthalate (PET) micro and nanoparticles in zebrafish early development
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Researchers exposed zebrafish embryos to PET plastic micro and nanoparticles at levels found in the environment and observed toxic effects including reduced tail movement, faster heart rates, and changes in eye development. The smaller nanoplastic particles were especially concerning because they are more easily absorbed by developing organisms. These findings suggest that PET plastic pollution in water could harm fish development, raising questions about effects on other species exposed through contaminated water.
Size- and polymer-dependent effects of polystyrene and polyethylene micro- and nanoplastics in zebrafish (Danio rerio)
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Researchers systematically compared polystyrene and polyethylene micro- and nanoplastics in zebrafish embryos and larvae, finding that nanoplastics caused mortality, impaired hatching, and disrupted swimming behavior at lower concentrations than microplastics, with surface adhesion to embryonic tissues emerging as a likely initiating mechanism for nanoplastic toxicity.
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