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A 21st century miniguide to fungal biotechnology

Mexican Journal of Biotechnology 2019 15 citations

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This molecular biology review covers advances in fungal genetics and biotechnology, including gene editing, genome sequencing, and transposable elements. It is a fundamental biology paper with no direct connection to environmental microplastic pollution.

Realising the biotechnological potential of fungi requires full appreciation of the molecular biology and genetics of this kingdom. We review recent advances in our understanding of fungal genetic structure as it might influence biotechnology; including introns, alternative splicing of primary transcripts, transposons (transposable elements, or TEs), heterokaryosis, ploidy and genomic variation, sequencing, annotation and comparison of fungal genomes, and gene editing. We end by indicating under-researched, but unique, aspects of fungal cell biology that offer opportunities for developing new strategies to manage the activities of fungi to our benefit. As a closing example, we discuss the potential of bioengineering fungi specifically for bioremediation of plastic wastes.

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