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Tissue Accumulation of Microplastics and Toxic Effects: Widespread Health Risks of Microplastics Exposure

˜The œhandbook of environmental chemistry 2020 16 citations

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Researchers reviewed widespread tissue accumulation of microplastics across mammalian species, including humans, documenting that ingested and inhaled particles deposit in organs including the liver, lungs, and gut, where they trigger oxidative stress, inflammation, and endocrine disruption with potential long-term health consequences.

Currently, ecological risks induced by small plastic particles, fibers, and debris with size less than 5 μm (microplastics, MPs) have attracted worldwide attention. Notably, terrestrial mammals and even human beings would ingest MPs through feeding,...

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Researchers reviewed the exposure routes, uptake mechanisms, and accumulation pathways of microplastics in the human body, concluding that the ubiquitous presence of these particles warrants urgent investigation into their long-term ecological and health consequences.

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Researchers reviewed the toxicological effects of ingested microplastics on human health, examining how these ubiquitous particles accumulate in the gastrointestinal tract and may cause inflammation, oxidative stress, and potential systemic harm across multiple organ systems.

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A comprehensive review documents how microplastics enter the human body through ingestion, inhalation, and skin contact, then reach the lungs, liver, kidneys, brain, and reproductive organs, triggering oxidative stress, inflammation, endocrine disruption, and genotoxicity. These biochemical pathways link microplastic exposure to serious chronic conditions including metabolic syndrome, neurodegenerative disease, reproductive dysfunction, and cancer.

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