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Human Health Effects
Nanoplastics
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Waterborne exposure of gilthead seabream (Sparus aurata) to polymethylmethacrylate nanoplastics causes effects at cellular and molecular levels
Journal of Hazardous Materials2020
107 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Camila Barría,
Camila Barría,
Miguel Oliveira
Ângela Barreto,
Ângela Barreto,
Ângela Barreto,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Lorena Franco‐Martínez,
Ângela Barreto,
Ângela Barreto,
Ângela Barreto,
Ângela Barreto,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
Miguel Oliveira
Mariana Teles,
I. Brandts,
Mariana Teles,
Camila Barría,
Camila Barría,
I. Brandts,
I. Brandts,
I. Brandts,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Ângela Barreto,
Ângela Barreto,
Ângela Barreto,
Manuel A. Martins,
Camila Barría,
Asta Tvarijonaviciute,
Mariana Teles,
Mariana Teles,
I. Brandts,
I. Brandts,
I. Brandts,
I. Brandts,
Manuel A. Martins,
Asta Tvarijonaviciute,
Manuel A. Martins,
Miguel Oliveira
Lluís Tort,
Manuel A. Martins,
I. Brandts,
Camila Barría,
Miguel Oliveira
Miguel Oliveira
Lluís Tort,
Manuel A. Martins,
Asta Tvarijonaviciute,
Asta Tvarijonaviciute,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Asta Tvarijonaviciute,
I. Brandts,
Manuel A. Martins,
I. Brandts,
Lorena Franco‐Martínez,
Miguel Oliveira
Miguel Oliveira
Ângela Barreto,
Miguel Oliveira
Manuel A. Martins,
Manuel A. Martins,
Miguel Oliveira
Manuel A. Martins,
Manuel A. Martins,
Manuel A. Martins,
Manuel A. Martins,
Manuel A. Martins,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Asta Tvarijonaviciute,
Asta Tvarijonaviciute,
Miguel Oliveira
Asta Tvarijonaviciute,
Miguel Oliveira
Miguel Oliveira
Mariana Teles,
Lorena Franco‐Martínez,
Lorena Franco‐Martínez,
Ângela Barreto,
Manuel A. Martins,
Miguel Oliveira
Lluís Tort,
Miguel Oliveira
Miguel Oliveira
Mariana Teles,
Asta Tvarijonaviciute,
Asta Tvarijonaviciute,
Manuel A. Martins,
Manuel A. Martins,
Manuel A. Martins,
Ângela Barreto,
Ângela Barreto,
Lorena Franco‐Martínez,
Lluís Tort,
Lluís Tort,
Miguel Oliveira
Manuel A. Martins,
Miguel Oliveira
Mariana Teles,
Asta Tvarijonaviciute,
Asta Tvarijonaviciute,
Asta Tvarijonaviciute,
I. Brandts,
Lluís Tort,
Lluís Tort,
Asta Tvarijonaviciute,
Lluís Tort,
Mariana Teles,
Lluís Tort,
Mariana Teles,
Miguel Oliveira
Mariana Teles,
Mariana Teles,
Miguel Oliveira
Mariana Teles,
Miguel Oliveira
Asta Tvarijonaviciute,
Mariana Teles,
Mariana Teles,
Mariana Teles,
Lluís Tort,
Manuel A. Martins,
Miguel Oliveira
Miguel Oliveira
Lluís Tort,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Lluís Tort,
Lluís Tort,
Mariana Teles,
Asta Tvarijonaviciute,
Mariana Teles,
Miguel Oliveira
Mariana Teles,
Mariana Teles,
Mariana Teles,
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Miguel Oliveira
Mariana Teles,
Mariana Teles,
Mariana Teles,
Lluís Tort,
Mariana Teles,
Mariana Teles,
Mariana Teles,
Miguel Oliveira
Summary
Gilthead seabream exposed to polymethylmethacrylate nanoplastics in water showed dose- and time-dependent changes in liver gene expression and plasma biomarkers, with upregulation of oxidative stress response genes at even the lowest tested concentration (0.001 mg/L).
This study evaluated the effect of a short-term exposure to 45 nm polymethylmethacrylate nanoplastics (PMMA-NPs) on the gilthead seabream (Sparus aurata), by assessing biomarkers at different levels of biological organization in liver and plasma. Fish were exposed via water to PMMA-NPs (0, 0.001, 0.01, 0.1, 1 and 10 mg L) and sampled after 24 and 96 h. Results showed a general up-regulation of mRNA levels of key genes associated with lipid metabolism (e.g. apolipoprotein A1 and retinoid X receptor). Together with the modulation of the lipid pathway genes we also found a global increase in cholesterol and triglycerides in plasma. Antioxidant-related genes (e.g. glutathione peroxidase 1) were also up-regulated after 24 h of exposure, but their expression levels returned to control afterwards. Total antioxidant capacity (TAC) was increased throughout the experiment, however at 96 h the antioxidant capacity became less efficient, reflected by an increase in the total oxidative status (TOS). Concomitantly, we found an increase in the erythrocytic nuclear abnormalities (ENAs) throughout the trial. Altogether, PMMA-NPs activated the organism's antioxidant defenses and induced alterations in lipid metabolism pathways and genotoxicity in the blood cells of gilthead seabream.