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Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling
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Researchers investigated how micro- and nanoplastics affect thyroid health and found that these particles can trigger a specific form of cell death called pyroptosis in thyroid follicular cells. The study suggests that this process is activated through NF-kB signaling pathways, providing new mechanistic insights into how environmental plastic pollution may contribute to thyroid toxicity.
Collectively, these findings provide novel mechanistic insights into MNP-induced thyroid toxicity and highlight the critical role of follicular cell pyroptosis, contributing to our understanding of the adverse health consequences associated with environmental plastic pollution.
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Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling
AI summary Read the abstract
Researchers found that micro- and nanoplastics induce pyroptosis (inflammatory cell death) in thyroid follicular cells through activation of NF-kB signaling, triggering thyroid toxicity in mice. The study demonstrated that both 5-micrometer microplastics and 50-nanometer nanoplastics administered orally for up to 8 weeks caused thyroid dysfunction, revealing a specific mechanism by which plastic particles may disrupt thyroid function.
Micro/nanoplastics induce thyroid follicular cell pyroptosis to trigger thyrotoxicity by activating NF-κB signaling
AI summary Read the abstract
Researchers found that micro- and nanoplastics induce pyroptosis (inflammatory cell death) in thyroid follicular cells through activation of NF-kB signaling, triggering thyroid toxicity in mice. The study demonstrated that both 5-micrometer microplastics and 50-nanometer nanoplastics administered orally for up to 8 weeks caused thyroid dysfunction, revealing a specific mechanism by which plastic particles may disrupt thyroid function.
Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment
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Researchers investigated the effects of polystyrene nanoplastics on thyroid-derived cell lines, finding rapid intracellular uptake, disruption of redox balance, and altered expression of thyroid hormone-related genes and proteins. The findings indicate that nanoplastics can directly disrupt thyroid cell function through oxidative stress and interference with hormone biosynthesis pathways.
Repeated oral exposure to polyethylene microplastics induces thyroid toxicity in rats: Evidence from in vivo toxicokinetics and multi-omics analyses
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Rats fed microplastics daily for 28 days developed thyroid problems, including lower thyroid hormone levels and swelling in thyroid tissue, at doses just 10 to 100 times higher than what people are estimated to consume daily. The plastic particles built up in organs and disrupted genes tied to thyroid function. This early evidence suggests everyday plastic exposure could affect thyroid health, though more research is needed to confirm risks in humans.
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