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Metabolomic Study of Heterotrophically Grown Chlorella sp. Isolated from Wastewater in Northern Sweden
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Researchers conducted a metabolomic study of a heterotrophically grown Chlorella strain isolated from wastewater in northern Sweden, finding distinct metabolic profiles and higher lipid contents under heterotrophic growth conditions compared to autotrophic cultivation.
There are numerous strains of Chlorella with a corresponding variety of metabolic pathways. A strain we previously isolated from wastewater in northern Sweden can grow heterotrophically as well as autotrophically in light and has higher lipid contents under heterotrophic growth conditions. The aims of the present study were to characterize metabolic changes associated with the higher lipid contents in order to enhance our understanding of lipid production in microalgae and potentially identify new compounds with utility in sustainable development. Inter alia, the amino acids glutamine and lysine were 7-fold more abundant under heterotrophic conditions, the key metabolic intermediate alpha-ketoglutarate was more abundant under heterotrophic conditions with glucose, and maltose was more abundant under heterotrophic conditions with glycerol than under autotrophic conditions. The metabolite 3-hydroxy-butyric acid, the direct precursor of the biodegradable plastic PHB (poly-3-hydroxy-butyric acid), was also more abundant under heterotrophic conditions. Our metabolomic analysis has provided new insights into the alga's lipid production pathways and identified metabolites with potential use in sustainable development, such as the production of renewable, biodegradable plastics, cosmetics, and nutraceuticals, with reduced pollution and improvements in both ecological and human health.
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Oxidative stress and metabolic process responses of Chlorella pyrenoidosa to nanoplastic exposure: Insights from integrated analysis of transcriptomics and metabolomics
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Researchers used integrated transcriptomics and metabolomics to reveal that the microalgae Chlorella pyrenoidosa responds to nanoplastic oxidative stress primarily through linoleic acid, glycine-serine-threonine, and arginine-proline metabolic pathways, identifying key driver genes that could be targeted through genetic engineering to reduce nanoplastic harm in aquatic ecosystems.
Influence of microplastics on microalgal performance during wastewater polishing
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Researchers studied how five common types of microplastics affect the green alga Chlorella vulgaris during wastewater treatment. They found that while microplastics reduced algal metabolism and growth, the organism maintained its ability to effectively remove nutrients from wastewater. The study demonstrates that Chlorella vulgaris is a robust candidate for bioremediation of microplastic-contaminated wastewater, even under pollutant stress.
Growth and Cell Size of Microalga Auxenochlorella protothecoides AS-1 under Different Trophic Modes
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Researchers compared the growth performance of a microalgal strain isolated from microplastic biofilm under different nutritional conditions. The study found that Auxenochlorella protothecoides AS-1 grew most effectively under mixotrophic conditions, reaching high biomass in just six days, suggesting potential applications in biotechnology and bioremediation.
Influence of microplastic exposure on nutrient uptake and growth performance of Chlorella vulgaris
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Researchers exposed Chlorella vulgaris to five common microplastic polymer types under varying nitrogen availability and light regimes, finding that HDPE and LDPE suppressed esterase activity while PS elevated it under nitrogen limitation — yet the alga maintained high nutrient removal efficiency (up to 94% nitrogen, >97.5% glucose) in most conditions, supporting its use in microplastic-contaminated wastewater treatment.
Gene expression, Antioxidant Responses, and metabolomic Profiling Reveal Chlorella vulgaris Mediated Protection against acetaminophen and microplastic Co-toxicity in Oreochromis niloticus
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In tilapia fish exposed to the drug acetaminophen combined with microplastics for 14 days, researchers measured increased inflammation, oxidative stress markers, and altered metabolism. Fish fed Chlorella (a type of algae) in their diet showed reduced inflammation and oxidative stress and more normal metabolic markers compared to fish not given Chlorella.
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