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Antidrug resistance in the Indian ambient waters of Ahmedabad during the COVID-19 pandemic

Journal of Hazardous Materials 2021 45 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, ‪Damià Barceló, Manish Kumar, Manish Kumar, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, Manish Kumar, Manish Kumar, Bhagwana Ram, ‪Damià Barceló, ‪Damià Barceló, Bhagwana Ram, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, ‪Damià Barceló, Manish Kumar, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, Manish Kumar, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, ‪Damià Barceló, Keisuke Kuroda, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, Christian Sonne, Tushara Chaminda, Kiran Dhangar, Pradeep Kumar Sharma, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, Manish Kumar, Manish Kumar, Manish Kumar, ‪Damià Barceló, Christian Sonne, Christian Sonne, ‪Damià Barceló, Jörg Rinklebe Jörg Rinklebe ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, Bhagwana Ram, Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, Alok Thakur, ‪Damià Barceló, Jörg Rinklebe ‪Damià Barceló, Jörg Rinklebe Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, Bhagwana Ram, Nirav P. Raval, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, Manish Kumar, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Jörg Rinklebe Jörg Rinklebe Keisuke Kuroda, Christian Sonne, Christian Sonne, Christian Sonne, Vaibhav Srivastava, Tushara Chaminda, Christian Sonne, Christian Sonne, Christian Sonne, Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Manish Kumar, Pradeep Kumar Sharma, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, Christian Sonne, ‪Damià Barceló, Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Jörg Rinklebe Jörg Rinklebe ‪Damià Barceló, Keisuke Kuroda, ‪Damià Barceló, Jörg Rinklebe ‪Damià Barceló, Abhay Kumar, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, Keisuke Kuroda, Christian Sonne, Nirav P. Raval, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, Jörg Rinklebe Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Vaibhav Srivastava, ‪Damià Barceló, Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, Jörg Rinklebe Jörg Rinklebe Jörg Rinklebe ‪Damià Barceló, Jörg Rinklebe Christian Sonne, Keisuke Kuroda, Jörg Rinklebe Jörg Rinklebe ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, Christian Sonne, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, Christian Sonne, ‪Damià Barceló, Jörg Rinklebe

Summary

Researchers compared antibiotic resistance patterns in Escherichia coli isolated from ambient water in Ahmedabad, India before and during the COVID-19 pandemic, finding increased multi-drug resistance during the pandemic period, likely linked to elevated antibiotic consumption.

Study Type Environmental

The ongoing COVID-19 pandemic increases the consumption of antimicrobial substances (ABS) due to the unavailability of approved vaccine(s). To assess the effect of imprudent consumption of ABS during the COVID-19 pandemic, we compare the 2020 prevalence of antidrug resistance (ADR) of Escherichia coli (E. coli) with a similar survey carried out in 2018 in Ahmedabad, India using SARS-CoV-2 gene detection as a marker of ABS usage. We found a significant ADR increase in 2020 compared to 2018 in ambient water bodies, harbouring a higher incidence of ADR E.coli towards non-fluoroquinolone drugs. Effective SARS-CoV-2 genome copies were found to be associated with the ADR prevalence. The prevalence of ADR depends on the efficiency of WWTPs (Wastewater Treatment Plants) and the catchment area in its vicinity. In the year 2018 study, prevalence of ADR was discretely distributed, and the maximum ADR prevalence recorded was ~60%; against the current homogenous ADR increase, and up to 85% of maximum ADR among the incubated E.coli isolated from the river (Sabarmati) and lake (Chandola and Kankaria) samples. Furthermore, wastewater treatment plants showed less increase in comparison to the ambient waters, which eventually imply that although SARS-CoV-2 genes and faecal pollution may be diluted in the ambient waters, as indicated by low C<sub>t</sub>-value and E.coli count, the danger of related aftermath like ADR increase cannot be nullified. Also, Non-fluoroquinolone drugs exhibited overall more resistance than quinolone drugs. Overall, this is probably the first-ever study that traces the COVID-19 pandemic imprints on the prevalence of antidrug resistance (ADR) through wastewater surveillance and hints at monitoring escalation of other environmental health parameters. This study will make the public and policyholders concerned about the optimum use of antibiotics during any kind of treatment.

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