We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Bisphenol S Leads to Cytotoxicity-Induced Antioxidant Responses and Oxidative Stress in Isolated Rainbow Trout (Oncorhyncus Mykiss) Hepatocytes
AI summary Read the abstract
Bisphenol S (BPS), widely used as a 'safer' substitute for BPA in plastics, caused oxidative stress and cell death in rainbow trout liver cells. The findings raise concerns that BPS—found in products marketed as BPA-free—may not be a safe alternative for fish health or for humans consuming contaminated seafood.
Abstract Background: Bisphenol S (BPS) is a chemical compound that is utilized in the plastic industry as an alternative to bisphenol A (BPA). The toxic effects of BPS in fish is less known and limited. Therefore, in the present study, it was aimed to investigate the influence of BPS on rainbow trout ( Oncorhyncus mykiss ) hepatocytes in vitro. Methods and Results: For this purpose, the hepatocytes of the fish were isolated, and then the cultured cells were treated with increasing concentrations of BPS (0, 15.63, 31.25, 62.50, 125, 250, and 500 µM) for 24 h. The cytotoxic impact of BPS was determined in the culture media using lactate dehydrogenase assay and then, the antioxidant defence indicators were assayed. The results showed that concentration-dependent increases were observed in the percentage of cytotoxicity. The superoxide dismutase activity was reduced, while the catalase and glutathione peroxidase activity was elevated with all of the BPS concentrations. The glutathione S-transferase (GST) activity was significantly increased with a BPS concentration of 31.25 µM or higher, while GST theta 1-1 activity was decreased with the same concentrations of BPS. The reduced glutathione content was decreased significantly with a BPS concentration of 31.25 µM or higher, and the malondialdehyde content increased with BPS concentrations of 125, 250, and 500 µM. Conclusions: The findings determined herein suggested that BPS causes cytotoxicity in fish hepatocytes and could lead to oxidative stress, resulting hepatotoxicity in fish. Thus, the utilization of BPS instead of BPA as safe alternative in industry should be re-evaluated in the future for environmental health.
More Papers Like This
In Vitro Effects of Bisphenol F on Antioxidant System Indicators in the Isolated Hepatocytes of Rainbow Trout (Oncorhyncus mykiss)
AI summary Read the abstract
Bisphenol F (BPF) — a common replacement for the plastic chemical BPA — caused dose-dependent cell death and oxidative stress in isolated liver cells from rainbow trout. This finding raises concerns that BPF, marketed as a safer alternative, may have similar toxic effects on aquatic animals and potentially humans.
Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)
AI summary Read the abstract
Researchers investigated the toxic effects of bisphenol A, a plastics-related endocrine disruptor, on common carp at different dose levels over 30 days. The study found dose-dependent reductions in blood cell counts, increased oxidative stress in the brain, liver, gills, and kidneys, and significant tissue damage, indicating that BPA exposure poses risks to aquatic organisms.
Sub‐Chronic Bisphenol‐A Toxicity in Climbing Perch, Anabas testudineus : Insight Into Metabolic Disruption, Oxidative Stress, and Histopathological Changes
AI summary Read the abstract
Researchers exposed climbing perch (Anabas testudineus) to sub-chronic doses of bisphenol-A, a plasticizer commonly released from degrading microplastics. The study found that BPA exposure caused significant metabolic disruption, oxidative stress, and histopathological damage in the fish, highlighting the indirect health risks that microplastic-derived chemicals pose to aquatic organisms.
Bisphenol S (BPS) Alters Xanthine Oxidoreductase Activity to Elevate Oxidative Stress Mediated Protein Carbonylation in Small Intestine of Rat ex vivo
AI summary Read the abstract
Bisphenol S (BPS), a replacement for the now-restricted bisphenol A commonly leached from food packaging plastics, was found to increase protein carbonylation and alter the xanthine oxidoreductase enzyme system in rat intestinal tissue, generating oxidative stress in a dose-dependent manner. This suggests that BPS is not a safe substitute for BPA and that plastics labeled as BPA-free may still pose significant chemical hazards to the digestive system.
Polystyrene Nanoplastics Induce Multi-Organ Toxicity in the Rainbow Trout (Oncorhynchus mykiss): An Integrated Assessment of Physiological, Immunological, and Molecular Responses
AI summary Read the abstract
Rainbow trout were exposed to polystyrene nanoplastics at three concentrations for 28 days and assessed for physiological, immunological, and molecular responses across multiple organs. NPs accumulated in liver, spleen, and intestine, causing dose-dependent oxidative stress, immune dysregulation, and altered gene expression, demonstrating multi-organ toxicity in a commercially important fish species.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.