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Clinical Trial ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 1 ? Systematic review or meta-analysis. Synthesizes findings across many studies. Strongest evidence. Environmental Sources Human Health Effects Marine & Wildlife Nanoplastics Remediation Sign in to save

Cell Cycle Control of Nanoplastics Internalization in Phytoplankton

ACS Nano 2021 91 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Neng Yan, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Ben Zhong Tang Ben Zhong Tang Ben Zhong Tang Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Neng Yan, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Wen‐Xiong Wang, Neng Yan, Ben Zhong Tang Ben Zhong Tang Wen‐Xiong Wang, Ben Zhong Tang Ben Zhong Tang

Summary

This study found that tiny nanoplastic particles are taken up by cells at different rates depending on the cell's growth stage, with cells in the dividing phase absorbing the most. This matters for human health because it suggests that actively growing tissues may be more vulnerable to nanoplastic accumulation.

Models
Human

Nanoparticles (NPs) for delivering chemotherapeutic drugs are now in clinical trials, and cellular uptake of NPs plays an important role in determining the drug delivery efficiency. Herein, we reported that the bioaccumulation and internalization of NPs were governed by the cell cycle. Specifically, we found that the bioaccumulation of NPs was more favored in the G<sub>2</sub>/M stages, followed by the S and G<sub>0</sub>/G<sub>1</sub> stages. We demonstrated that three key parameters-clathrin-mediated endocytosis capacity, algal cell membrane permeability, and exopolymer substance (EPS) thickness-were critical in the bioaccumulation of NPs during the cell cycling process. Over the 24-h average duration of cell cycle, clathrin-mediated endocytosis capacity was much higher at the S stage than that at the G<sub>0</sub>/G<sub>1</sub> and G<sub>2</sub>/M stages. Besides, cell membrane permeability was measured to be higher in S and G<sub>2</sub>/M stages while the lowest in G<sub>0</sub>/G<sub>1</sub> stage. We have also identified the change of EPS thickness during the 24-h cell cycle. Transition from G<sub>0</sub>/G<sub>1</sub> to S and G<sub>2</sub>/M induced the attenuation in EPS thickness, and the thinnest EPS was found at the end of mitosis. The cell cycle control NPs internalization were further verified by exposing Ag nanoparticles to algae at different cell cycle stages, confirming the important roles of EPS thickness and cell cycle control in the dynamic internalization processes. The present study highlights the important roles of cell cycle controlling the NPs bioaccumulation and internalization, with possible implications in maximizing NPs internalization efficiency while reducing the cost.

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