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Transcriptome-wide m6A profiling reveals mRNA post-transcriptional modification of boar sperm during cryopreservation
Summary
Researchers mapped chemical modifications (m6A tags) on messenger RNA in boar sperm during freeze preservation for the first time, finding these epigenetic marks are linked to sperm motility and cell survival — offering new insight into why sperm quality declines during cryopreservation.
Our study is the first to reveal the dynamic m6A modification of mRNAs in boar sperm during cryopreservation. These epigenetic modifications may affect mRNA expression and are closely related to sperm motility, apoptosis, and metabolism, which will provide novel insights into understanding of the cryoinjuries or freezability of boar sperm during cryopreservation.
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