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Unravelling ultrafine particulate matter and micro nano plastic's mechanisms of impact on fetal health (UPRISE)

Zenodo (CERN European Organization for Nuclear Research) 2025
José Antonio Díaz Olivares, Imelda Ontoria Oviedo, ALBA C RUIZ GAITAN, Lía Pitti, Carlos Fito

Summary

The UPRISE research project is investigating how airborne ultrafine particles and micro-nanoplastics affect fetal health, using exposure modeling, biological pathway analysis, and a clinical study of pregnant women to identify mechanisms linking prenatal pollution to noncommunicable disease risk.

Body Systems

The UPRISE project investigates how air pollution—specifically ultrafine particles (UFPs) and micro-nanoplastics(MNPs)—affects fetal development and increases the risk of adverse birth outcomes (ABOs) linked to later noncommunicablediseases (NCDs). By developing exposure databases, advanced models, and a clinical study onpregnant participants, UPRISE will uncover key biological pathways underlying these effects. The project will buildcausal models to establish evidence-based links between pollutant exposure and ABOs and will translate findingsinto policy tools to inform European air quality standards. Ultimately, UPRISE aims to reduce the long-term healthburden of pollution-related prenatal impacts.

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