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Unravelling ultrafine particulate matter and micro nano plastic's mechanisms of impact on fetal health (UPRISE)

Zenodo (CERN European Organization for Nuclear Research) 2025
José Antonio Díaz Olivares, Imelda Ontoria Oviedo, ALBA C RUIZ GAITAN, Lía Pitti, Carlos Fito

Summary

The UPRISE project described here investigates how ultrafine particles and micro-nanoplastics from air pollution affect fetal development and birth outcomes, developing exposure databases, advanced models, and a clinical study on pregnant participants to build causal evidence.

Body Systems

The UPRISE project investigates how air pollution—specifically ultrafine particles (UFPs) and micro-nanoplastics(MNPs)—affects fetal development and increases the risk of adverse birth outcomes (ABOs) linked to later noncommunicablediseases (NCDs). By developing exposure databases, advanced models, and a clinical study onpregnant participants, UPRISE will uncover key biological pathways underlying these effects. The project will buildcausal models to establish evidence-based links between pollutant exposure and ABOs and will translate findingsinto policy tools to inform European air quality standards. Ultimately, UPRISE aims to reduce the long-term healthburden of pollution-related prenatal impacts.

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