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Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice
Summary
This study demonstrated that melatonin administration suppressed NF-kB-mediated allergic airway inflammation in epicutaneously sensitized mice, suggesting that antioxidant treatment may be a viable strategy for preventing progression of atopic disease from skin sensitization to lung inflammation.
To mitigate the development of the atopic march, antioxidants such as MT may be imperative to inhibit NF-κB activation in the lung, especially after the onset of AD.
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