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Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos
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Researchers used high-throughput zebrafish embryo imaging to show that surface functionalization determines the toxicity of metal nanoparticles and nanoplastics, with surface charge and coating chemistry more predictive of hatching failure and malformation rates than particle composition alone.
High throughput imaging is used to assess hatching, lethality and malformations in zebrafish embryos and is suitable for hazard ranking of different nanomaterials.
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Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next
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This review integrates findings from studies on how polystyrene nanoplastics affect zebrafish embryo development, a widely used model for understanding toxicity. Researchers found that the functional coating on nanoplastic surfaces had a greater influence on toxic effects than particle size or concentration alone. The study highlights that surface chemistry is a critical and often overlooked factor in nanoplastic toxicity, and calls for more standardized study designs to improve comparability across research.
Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos
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Researchers prepared realistic polyethylene terephthalate nanoplastics and found that both size and surface coating significantly influenced their toxicological impacts on zebrafish embryos, providing an early hazard assessment for PET nanoplastics.
Effect of functional groups of polystyrene nanoplastics on the neurodevelopmental toxicity of acrylamide in the early life stage of zebrafish
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This zebrafish study found that nanoplastics with different surface coatings altered the neurodevelopmental toxicity of acrylamide, a common food contaminant formed during cooking. Positively charged nanoplastics worsened brain development problems by increasing acrylamide absorption, while negatively charged ones had a partially protective effect. The findings show that the surface chemistry of nanoplastics matters greatly for how they interact with other environmental contaminants to affect brain development.
Size- and polymer-dependent effects of polystyrene and polyethylene micro- and nanoplastics in zebrafish (Danio rerio)
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Researchers systematically compared polystyrene and polyethylene micro- and nanoplastics in zebrafish embryos and larvae, finding that nanoplastics caused mortality, impaired hatching, and disrupted swimming behavior at lower concentrations than microplastics, with surface adhesion to embryonic tissues emerging as a likely initiating mechanism for nanoplastic toxicity.
Simulated Environmental Nanoplastics Induce Zebrafish Developmental Toxicity and Stress Response
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Scientists exposed zebrafish embryos to nanoplastics that were specially broken down to mimic how plastic actually degrades in oceans and rivers, and found they caused more harm than the lab-made plastic beads typically used in research, stunting growth, slowing hatching, and triggering stress hormone spikes even at very low doses. Because these effects showed up at concentrations similar to what's found in real water sources, the findings suggest current safety testing may be underestimating the risks nanoplastics pose to both aquatic life and, potentially, to people who drink that water or eat seafood from it.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.