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Increase in germline methyltransferases governing the methylation of histone H3K9 is associated with transgenerational nanoplastic toxicity in Caenorhabditis elegans
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Researchers found that increased germline methyltransferases responsible for histone H3K9 methylation are associated with transgenerational nanoplastic toxicity in the nematode C. elegans, suggesting epigenetic mechanisms underlie cross-generational plastic harm.
Our data demonstrated the association of the increase in germline methyltransferases required for methylation of H3K9 with transgenerational nanoplastic toxicity in nematodes.
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Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans
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Researchers showed that polystyrene nanoplastics at environmentally predicted doses suppress germline histone acetyltransferases and deacetylases in C. elegans, and that silencing these chromatin-regulating enzymes worsened toxicity across multiple generations by dysregulating signaling ligands — identifying histone deacetylase inhibition as the molecular initiating event in an epigenetic adverse outcome pathway.
Nanoplastics cause transgenerational toxicity through inhibiting germline microRNA mir-38 in C. elegans
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Researchers used the model organism C. elegans to investigate how nanoplastic exposure causes transgenerational toxicity through effects on germline microRNA. The study found that polystyrene nanoparticles decreased expression of germline miRNA mir-38, and that overexpressing this miRNA conferred resistance to transgenerational toxicity. The findings suggest that nanoplastics can cause heritable toxic effects across generations by disrupting germline gene regulation.
Nanoplastic Exposure at Predicted Environmental Concentrations Induces Activation of Germline Ephrin Signal Associated with Toxicity Formation in the Caenorhabditis elegans Offspring
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Researchers discovered that nanoplastic exposure at environmentally relevant concentrations activates the germline Ephrin signaling pathway in C. elegans, revealing a molecular mechanism underlying transgenerational toxicity formation in offspring.
Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans
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When roundworms were exposed to sun-aged polystyrene nanoplastics at environmentally relevant levels, the reproductive damage passed down to unexposed future generations through changes in gene-regulating chemical marks called histone methylation. Sun-aged nanoplastics caused more severe fertility problems than fresh ones, and these effects persisted for two generations after exposure stopped. This study is alarming because it shows nanoplastic exposure could cause hereditary reproductive harm without changing DNA itself.
Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans
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Researchers found that nanoplastics at environmentally relevant concentrations suppress the germline G protein-coupled receptor CED-1 in C. elegans, triggering transgenerational toxicity by upregulating histone methylation enzymes and disrupting downstream secreted ligands across multiple generations.
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