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Competitive and/or cooperative interactions of graphene-family materials and benzo[a]pyrene with pulmonary surfactant: a computational and experimental study
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Researchers studied how graphene-based nanomaterials and benzo[a]pyrene — a toxic pollutant — interact with the thin fluid layer lining the lungs, finding that graphene readily absorbs the pollutant and carries it to the lung surface where it can disrupt the protective surfactant layer. This suggests that nanomaterials, similar to nanoplastics, could act as carriers that concentrate and deliver harmful chemicals deeper into the respiratory system.
GFMs showed high adsorption capacity towards BaPs to form nanocomposites. Upon deposition of GFMs carrying BaPs at the alveolar air-water interface covered by a thin PS layer, the interactions of GFM-PS, GFM-BaP and BaP-PS determined the interfacial processes of BaP solubilization, GFM translocation and PS perturbation.
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Joint Interactions of Graphene and Benzo[a]pyrene With Pulmonary Surfactant
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Researchers studied how graphene nanoparticles and benzo[a]pyrene (a combustion pollutant) interact with lung surfactant, the protective film lining the air sacs of the lungs. The findings have implications for understanding how inhaled nanoparticles, including nanoplastics, may penetrate the body's first line of respiratory defense.
Understanding interactions between oligomeric plastic and lung-sufactants underpinning inhalation risks of airborne plastics
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Researchers investigated how oligomeric plastic particles interact with lung surfactant bilayers to understand inhalation risks, proposing that as plastics break down to oligomeric sizes through environmental degradation they may penetrate and disrupt the protective surfactant layer lining the lungs.
The effects of adsorbed benzo(a)pyrene on dynamic behavior of polystyrene nanoplastics through phospholipid membrane: A molecular simulation study
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Researchers used molecular simulations to show that benzo(a)pyrene adsorbed onto polystyrene nanoplastics alters how the particles interact with and penetrate phospholipid membranes, suggesting that pollutant-coated nanoplastics may pose different biological risks than pristine ones.
Toxicological assessment of benzo(a)pyrene - coated PET nanoplastics in vitro on a 3D model of the human bronchial epithelium
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Researchers assessed the in vitro toxicity of PET nanoplastics coated with benzo(a)pyrene on airway epithelial cells, simulating inhalation of pollutant-loaded particles. The combination of nanoplastics and PAH contamination produced stronger toxic effects than either stressor tested alone.
Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film
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Researchers used molecular dynamics simulations to model how inhaled nanoplastics interact with lung surfactant fluid at the air-water interface in the lungs. They found that lung surfactant molecules spontaneously coat nanoplastics to form coronas, and that some plastic types can be dissolved by lung surfactant, potentially increasing the bioavailability of toxic additives. The study suggests that nanoplastics could disrupt normal lung surfactant function, raising concerns about respiratory health effects.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.