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Evaluation of Oxidative Stress and Genotoxicity Induced by Triclosan in the Freshwater Fish, Anabas testudineus (Bloch, 1792)
Summary
Researchers investigated oxidative stress and genotoxicity of triclosan in the freshwater fish Anabas testudineus, exposing fish to sublethal and environmental concentrations for up to 60 days and measuring antioxidant biomarkers, lipid peroxidation, micronucleus frequency, and comet assay results in gonad tissue and peripheral erythrocytes.
The antimicrobial property of triclosan benefits human in many consumer products, while its adverse effects on non-target organisms raise environmental concern. In this study we attempted to investigate possible role of triclosan in the antioxidant defense system and genotoxicity in the fish, Anabas testudineus. Fish were exposed to the sublethal (176.7 µg L-1) and environment concentrations (0.009 and 9 µg L-1) of triclosan for 4, 7, 30, and 60 days along with the control groups. Oxidative stress of triclosan was evaluated using biomarkers such as glutathione reductase, levels of reduced glutathione, hydrogen peroxide generation, lipid peroxidation, and protein carbonyl content in gonads. Besides, the frequencies of micronucleus, nucleo-cytoplasmic abnormalities, and comet assay were performed to estimate the genetic damage in the peripheral erythrocytes. Triclosan caused a significant (P
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