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Oral administration of TiO2 nanoparticles during early life impacts cardiac and neurobehavioral performance and metabolite profile in an age- and sex-related manner
Summary
Researchers found that feeding titanium dioxide nanoparticles (a common ingredient in food, sunscreen, and paint) to young rats disrupted heart function, brain chemistry, and metabolism in ways that differed by age and sex, with female pups showing greater harm. The findings raise concerns about early-life exposure to nanoparticles that enter the food supply and environment.
Oral administration of TiO2 NP to rat pups impacted basic cardiac and neurobehavioral performance, neurotransmitters and related metabolites concentrations in brain tissue, and the biochemical profiles of plasma. The findings suggested that female pups were more likely to experience adverse outcome following early life exposure to oral TiO2 NP than male pups. Collectively the data from this exploratory study suggest oral administration of TiO2 NP cause adverse biological effects in an age- and sex-related manner, emphasizing the need to understand the short- and long-term effects of early life exposure to TiO2 NP.
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