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Effects of polyvinyl chloride microplastics on reproduction, oxidative stress and reproduction and detoxification-related genes in Daphnia magna

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 2022 78 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Jiale Zhang, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Haoyang Zhao, Haoyang Zhao, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Ji Fei Cai, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yousef Sultan, Jiale Zhang, Yang Liu, Yang Liu, Jiale Zhang, Yang Liu, Yang Liu, Haiyan Fang, Junguo Ma Yang Liu, Bangjun Zhang, Yang Liu, Yang Liu, Junguo Ma

Summary

Researchers exposed water fleas (Daphnia magna) to PVC microplastics of two different sizes and measured effects on reproduction, oxidative stress, and gene expression. They found that smaller microplastics caused greater reproductive impairment and stronger oxidative stress responses, along with changes in genes related to reproduction and detoxification. The study demonstrates that microplastic size is an important factor in determining toxicity to freshwater invertebrates.

Polymers

PVC

Body Systems

Reproductive

Models

Daphnia

Study Type Environmental

The drastic increase of microplastics (MPs) in aquatic environment has become a serious threat to marine and freshwater ecosystems. However, little information is available regarding the potential detrimental effects of polyvinyl chloride microplastics (PVC-MPs) on aquatic organisms. This study investigated the changes of reproduction parameters, oxidative stress and the expression of reproduction and detoxification-related genes in Daphnia magna after exposed to 2 ± 1 and 50 ± 10 μm PVC-MPs. The results showed that chronic exposure to 2 ± 1 μm PVC-MPs prolonged days to the first brood, increased total number of broods per female and frequency of molting per adult, decreased offspring number at first brood and total number of offspring per female in D. magna. Moreover, 2 ± 1 μm PVC-MPs also disturbed the activities of SOD and CAT, increased GSH and MDA levels. The expression of Vtg, SOD, CAT, CYP314 and CYP360A8 genes also exhibited different response patterns depending on exposure time. Furthermore, 50 ± 10 μm PVC-MPs decreased offspring at first brood and Vtg mRNA level, increased the transcription levels and activities of SOD and CAT. These results suggest that the presence of PVC-MPs in aquatic environment may cause reproduction toxicity by disrupting the reproduction and detoxification-related genes expression and inducing oxidative stress in D. magna.

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