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A Systematic Review of the Effects of Bisphenol Analogs on Embryonic Development and Cytoskeletal Organization of Zebrafish (Danio rerio) Embryos
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This systematic review examines how bisphenol A analogs, chemicals used as replacements for BPA in plastics, affect zebrafish embryo development. These findings are concerning because BPA substitutes are found in many plastic products and may cause similar hormone-disrupting effects as BPA, potentially affecting human development and reproductive health.
Recent research has raised concerns about widespread exposure to chemicals that resemble bisphenol A (BPA) structurally or functionally. Because of the strict regulations governing production and use, various bisphenol analogs to replace BPA have increased. Some analogs have been reported to have disruptive physiological and endocrine effects. This study focuses on the impact of bisphenol A analogs on zebrafish embryos. The effect of bisphenol analogs is a major concern, prompting researchers to conduct numerous related studies. Regrettably, previous research has not focused on embryonic health. A systematic search strategy based on the RepOrting Standards for Systematic Evidence Syntheses (ROSES) guidelines was used. Three central journal repositories were used: Scopus, Web of Science, and ScienceDirect. Thirteen articles were discovered through search efforts and will be thoroughly examined. Bisphenol analogs were unearthed to have similar adverse effects on embryonic health as bisphenol-A. This study clarified how bisphenol A analogs affect embryonic development and cytoskeletal organization in the zebrafish model by disrupting the endocrine, cardiovascular, nervous, reproductive, and other systems. To thoroughly investigate these issues, more research on each source, metabolic pathway, exposure mechanisms, and effects on organisms is required.
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This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.
Use of zebrafish (Danio rerio) as a model for research in toxicological studies
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This review explains why zebrafish (Danio rerio) are a valuable model organism for toxicology research, summarizing how their biology, genetics, and organ systems resemble those of humans enough to yield insights about human health risks. Zebrafish are widely used in microplastic toxicology studies, and this review provides context for understanding the significance of zebrafish findings for human health. The paper covers applications across disease modeling and environmental toxicology.
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Bisphenol Analogs in Aquatic Environments and Their Effects on Marine Species—A Review
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This review summarized concentrations of bisphenol A analogs found across aquatic environments globally and assessed their toxic effects on marine species, finding that many BPA substitutes show similar endocrine-disrupting, oxidative, and genotoxic activity to the compound they replaced. The findings raise concerns that current BPA alternatives may not represent a meaningful safety improvement for aquatic ecosystems.
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