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Microplastics in septum after left bundle branch pacing: evidence from animal experiment
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Researchers implanted cardiac pacemaker leads (left bundle branch pacing) in ten beagles and found microplastics in the heart septum tissue after 6 weeks, providing the first experimental evidence that medical device implantation can deposit microplastics in cardiac tissue.
Abstract Background and Objective Microplastics (MPs) pose a significant health risk due to their pervasive presence and potential adverse effects. left bundle branch pacing (LBBP) is a novel physiological pacing modality, which characteristics with deep fixation of the lead into the septum. Whether MPs could be detected or not in septum after LBBP is unknown. Methods Ten beagles were selected to receive LBBP implantation. The C315 Sheath with the SelectSecure pacing lead (Model 3830) were used for LBBP. After 6 weeks follow-up, the animals were killed and the septum were taken and analyzed using Hematoxylin-Eosin staining approach. Results MPs was detected in septum of four LBBP canines (40.0%), with a mean maximum cross-sectional area of 81750 ± 8655.4 μm2. The mean distance between MPs and the septal cavity by LBBP lead was 522.5 ± 75.9μm. All MPs were surrounded by inflammatory cells. Conclusions Our study for the first time demonstrated that MPs could be detected in canine septum after LBBP implantation. This promising pacing modality may be a new route for MPs to enter the human body.Hematoxylin-Eosin staining in a canine
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