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Population-dependent stress response of bivalve mollusc Unio tumidus to ibuprofen, microplastic and their mixture

Research Square (Research Square) 2022 Score: 35 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Tetiana Matskiv, Tetiana Matskiv, Оksana Stoliar Vira Khoma, Tetiana Matskiv, Оksana Stoliar Brigita Gylytė, Viktoria Martinyuk, Vira Khoma, Brigita Gylytė, Viktoria Martinyuk, Tetiana Matskiv, Tetiana Matskiv, Tetiana Matskiv, Lesya Gnatyshyna, Tetiana Matskiv, Brigita Gylytė, Vira Khoma, Brigita Gylytė, Vira Khoma, Lesya Gnatyshyna, Vira Khoma, Vira Khoma, Vira Khoma, Vira Khoma, Vira Khoma, Tetiana Matskiv, Tetiana Matskiv, Оksana Stoliar Tetiana Matskiv, Kateryna Orlova-Hudim, Lesya Gnatyshyna, Lesya Gnatyshyna, Halyna Tulaidan, Vira Khoma, Lesya Gnatyshyna, Kateryna Orlova-Hudim, Оksana Stoliar Halyna Tulaidan, Halyna Tulaidan, Brigita Gylytė, Оksana Stoliar Vira Khoma, Lesya Gnatyshyna, Lesya Gnatyshyna, Brigita Gylytė, Kateryna Orlova-Hudim, Оksana Stoliar Оksana Stoliar Lesya Gnatyshyna, Kateryna Orlova-Hudim, Levonas Manusadžianas, Halyna Tulaidan, Brigita Gylytė, Brigita Gylytė, Оksana Stoliar Оksana Stoliar Levonas Manusadžianas, Lesya Gnatyshyna, Оksana Stoliar Levonas Manusadžianas, Оksana Stoliar Levonas Manusadžianas, Оksana Stoliar Оksana Stoliar

Summary

Researchers exposed freshwater mussels (Unio tumidus) from both pristine and contaminated populations to ibuprofen, polyethylene microplastics, and their combination for 14 days, comparing antioxidant enzyme responses, oxidative damage markers, and lysosomal stability. They found population-dependent differences in stress responses, with the contaminated population showing more pronounced reactions to ibuprofen and the pristine population responding more strongly to microplastics alone.

Body Systems

Digestive

Study Type Environmental

Abstract Even though bivalve molluscs are recognized as bioindicators of freshwater quality, their responses to multiple stressors are unpredictable. This study aims to elucidate the inter-population peculiarities of the effect in the sub-chronic environmentally relevant exposure to novel contaminants. The specimens of Unio tumidus from pristine (Pr) and contaminated (Ct) areas were treated with ibuprofen (IBU, 0.8 µg L − 1 ), microplastic (MP, 1.0 mg L − 1 , size 0.1–0.5 mm), or their combination (Mix) for 14 days. Untreated mussels (PrC- and CtC-groups) served as controls. The PrC-group had higher levels of antioxidants Mn-SOD, Cu,Zn-SOD, catalase, and cholinesterase (AChE) as well as lesser levels of oxidative lesions (TBARS and protein carbonyls) in digestive gland than the CtC-group, confirming different quality of life in two populations. However, lysosomal stability was similar in all studied groups. IBU induced antioxidant and AChE responses and lysosomal integrity in the Ct-group, only. MP caused the up-regulation of Mn-SOD and TBARS, and the suppression of Cu,Zn-SOD solely in the Pr-group. Discriminant analyses indicated lesser differences between Pr-groups, demonstrating their resistance across all treatments compared to Ct-groups. Most remarkable response was revealed in the CtIBU-group, and the alleviation of individual effects was established in combined exposures. The qualification of stress-neutral and stress-positive populations were proposed for Pr- and Ct-populations correspondingly. Inter-population peculiarities must be taken into consideration when environmental impact of MP and pharmaceuticals is evaluated.

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