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Plastic particles in medicine: A systematic review of exposure and effects to human health

Chemosphere 2022 78 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Ponnusamy Manogaran Gopinath, Ponnusamy Manogaran Gopinath, Ponnusamy Manogaran Gopinath, Ponnusamy Manogaran Gopinath, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Venkatachalam Deepa Parvathi, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Venkatachalam Deepa Parvathi, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Yoghalakshmi Nagarajan, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Ponnusamy Manogaran Gopinath, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Venkatachalam Deepa Parvathi, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Srinivasan Madhan Kumar, Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Pazhamthavalathil Anil Athulya, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Venkatachalam Deepa Parvathi, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran Natarajan Chandrasekaran Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Amitava Mukherjee, Natarajan Chandrasekaran

Summary

Medical plastics including bags, containers, and administration sets release micro- and nanoplastics along with chemical additives that can interact with pharmaceutical constituents, creating an understudied route of direct human exposure. Both primary exposure (during medical treatment) and secondary environmental exposure (from hospital plastic waste disposal) represent potential health hazards.

Study Type Review

Single-use plastics (SUPs) have become an essential constituent of our daily life. It is being exploited in numerous pharmaceutical and healthcare applications. Despite their advantages and widespread use in the pharma and medical sectors, the potential clinical problems of plastics, especially the release of micro-nanoplastics (MNPs) and additives from medical plastics (e.g. bags, containers, and administrative sets) and sorption of drugs remain understudied. Certainly, the MNPs are multifaceted stressors that cause detrimental effects to the ecosystem and human health. The origin and persistence of MNPs in pharmaceutical products, their administration to humans, endurance and possible health implication, translocation, and excretion have not been reviewed in detail. The prime focus of this article is to conduct a systematic review on the leaching of MNPs and additives from pharmaceutical containers/administrative sets and their interaction with the pharmaceutical constituents. This review also explores the primary and secondary routes of MNPs entry from healthcare plastic products and their potential health hazards to humans. Furthermore, the fate of plastic waste generated in hospitals, their disposal, and associated MNPs release to the environment, along with preventive, and alternative measures are discussed herein.

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