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Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

Journal of Hazardous Materials 2022 367 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Chen Wang, Pengfei Wu, Pengfei Wu, Pengfei Wu, Guodong Cao Pengfei Wu, Pengfei Wu, Pengfei Wu, Ming Hung Wong, Zongwei Cai, Pengfei Wu, Pengfei Wu, Siyi Lin, Pengfei Wu, Pengfei Wu, Pengfei Wu, Siyi Lin, Siyi Lin, Zhu Yang, Pengfei Wu, Zongwei Cai, Pengfei Wu, Zongwei Cai, Zongwei Cai, Pengfei Wu, Guodong Cao Guodong Cao Guodong Cao Zhu Yang, Zongwei Cai, Ming Hung Wong, Ming Hung Wong, Chen Wang, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Jiabin Wu, Pengfei Wu, Zongwei Cai, Zongwei Cai, Pengfei Wu, Guodong Cao Siyi Lin, Chen Wang, Hangbiao Jin, Zhu Yang, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Hangbiao Jin, Chen Wang, Zongwei Cai, Zongwei Cai, Chen Wang, Chen Wang, Zongwei Cai, Ming Hung Wong, Pengfei Wu, Zongwei Cai, Chen Wang, Pengfei Wu, Zongwei Cai, Zongwei Cai, Zongwei Cai, Hangbiao Jin, Zongwei Cai, Zongwei Cai, Zongwei Cai, Hangbiao Jin, Zongwei Cai, Pengfei Wu, Zongwei Cai, Hangbiao Jin, Guodong Cao Zongwei Cai, Pengfei Wu, Ming Hung Wong, Zhu Yang, Zhu Yang, Pengfei Wu, Ming Hung Wong, Zhu Yang, Ming Hung Wong, Ming Hung Wong, Pengfei Wu, Zongwei Cai, Zongwei Cai, Zongwei Cai, Zongwei Cai, Zhu Yang, Hangbiao Jin, Ming Hung Wong, Zongwei Cai, Zongwei Cai, Ming Hung Wong, Ming Hung Wong, Zongwei Cai, Zhu Yang, Zongwei Cai, Ming Hung Wong, Zongwei Cai, Zongwei Cai, Zongwei Cai, Zongwei Cai, Zongwei Cai, Ming Hung Wong, Guodong Cao

Summary

This review traces how microplastics move through the human body after being swallowed or inhaled, covering absorption, distribution, metabolism, and excretion. An adult may consume tens of thousands of microplastic particles each year through table salt and drinking water alone, and once inside, smaller particles can spread to different organs. The findings highlight that both the plastics themselves and the chemicals attached to them could pose health risks, though more research is needed to understand the full impact.

Body Systems

Integumentary Respiratory

Study Type In vivo

Microplastics (MPs; <5 mm) in the biosphere draws public concern about their potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation, and dermal contact. Ingestion and inhalation are the two major exposure pathways. An adult may consume approximately 5.1 × 10 items from table salts and up to 4.1 × 10 items via drinking water annually. Meanwhile, MP inhalation intake ranges from 0.9 × 10 to 7.9 × 10 items per year. The intake of MPs would be further distributed in different tissues and organs of humans depending on their sizes. The excretion has been discussed with the possible clearance ways (e.g., urine and feces). The review summarized the absorption, distribution, metabolic toxicity and excretion of MPs together with the attached chemicals. Moreover, the potential implications on humans are also discussed from in vitro and in vivo studies, and connecting the relationship between the physicochemical properties and the potential risks. This review will contribute to a better understanding of MPs as culprits and/or vectors linking to potential human health hazards, which will help outline the promising areas for further revealing the possible toxicity pathways.

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