Wastewater plastisphere enhances antibiotic resistant elements, bacterial pathogens, and toxicological impacts in the environment

Microplastics (MPs) are plastic particles with a size <5 mm that have raised alarming concerns owing to their ecological and human health impacts. They are largely released into the environment through the dumping of plastic waste and wastewater from treatment plants, domestic sewage, agricultural runoff, and industrial sources. Conventional wastewater treatment plants (WWTPs) are unable to remove micro and nano-sized plastic particles, which end up in the natural aquatic and terrestrial environment, causing multifaceted toxic impacts. Moreover, plastics in wastewater generate biofilm that potentially enriches antibiotic resistant bacteria (ARBs), antibiotic resistant genes (ARGs), and bacterial pathogens, which can largely impact antibiotic resistance development among organisms in the environment and transfer to humans through the food chain. Therefore, the current review aims to highlight the potential role of wastewater plastisphere in the enrichment and dissemination of ARBs, ARGs, and potential bacterial pathogens through mobile genetic elements (MGEs) in the environment. Further, the interaction of wastewater MPs with organic and inorganic contaminants and the associated ecological and human health impacts have been presented. Last but not the least, control strategies and future research perspectives on wastewater plastisphere are also highlighted.