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In-silico Deterioration of Plastic by Dietzia Maris Strain Cytochrome P450 Cyp153a16
Summary
Researchers used in-silico methods to predict the plastic degradation affinity of cytochrome P450 CYP153A16 from Dietzia maris, analysing its binding interactions with polycarbonate and phenol formaldehyde polymers using sequence alignment, phylogenetic analysis, protein modelling, and molecular docking to identify potential enzymatic degradation pathways.
Microbial degradation is a supportive method to treat the environmental pollution expanding due to excess production of plastic waste. Cytochrome P450 is highly effective enzyme for plastic degradation and many other pollutants due to vast range of substrate specificity. The present study was designed to predict the degradation affinity of cytochrome P450 for two types of plastic that were polycarbonate and phenol formaldehyde. It was also focused on identifying newly emerging harmful plastic for degradation and to determine their toxicity level. Maximum number of essential tools were applied to design this study of plastic degradation. The sequence of targeted strain was retrieved from NCBI and subjected to multiple sequence alignment and phylogenetic analysis. Protein model was generated and purified after the translation of gene into protein.