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Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development
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This review covers methods for detecting and quantifying nanoplastics in environmental samples, highlighting the significant analytical challenges posed by their small size. Techniques including pyrolysis-GC/MS and single-particle ICP-MS are discussed as promising approaches.
The prolonged perturbation of the immune system following the release of a plethora of self-molecules (known as damage-associated molecular patterns, DAMPs) by stressed or dying cells triggers acute and chronic pathological responses. DAMPs are commonly released after plasma membrane damage or complete rupture due to immunogenic cell death (ICD), upon numerous stressors including infectious and toxic agents. The set of DAMPs released after ICD include mature proinflammatory cytokines and alarmins, but also polymeric macromolecules. These self-intracellular components are recognized by injured and healthy surrounding cells via innate receptors, and induce upregulation of stress-response mechanisms, including inflammation. In this review, by overstepping the simple toxicological evaluation, we apply ICD and DAMP concepts to silica cytotoxicity, providing new insights on the mechanisms driving the progress and/or the exacerbation of certain SiO2-related pathologies. Finally, by proposing self-DNA as new crucial DAMP, we aim to pave the way for the development of innovative and easy-to-perform predictive tests to better identify the hazard of fine and ultrafine silica particles. Importantly, such mechanisms could be extended to nano/micro plastics and diesel particles, providing strategic advice and reports on their health issues.
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The Immunotoxic Effects of Environmentally Relevant Micro- and Nanoplastics
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Researchers characterized the immunotoxic effects of over 20 types of micro- and nanoplastic particles on macrophages and dendritic cells, finding that physicochemical properties such as size, shape, polymer type, and surface oxidation strongly influence immune cell responses.
Advancements in environmental nanoplastics research
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This review synthesises advances in environmental nanoplastics research, discussing distinctions between nanoplastics and microplastics in physicochemical properties, limitations in current analytical methods for environmental samples, and gaps between laboratory exposure studies and real-world concentrations. The authors highlight emerging evidence of nanoplastics in human organs and excretions and argue that methodological breakthroughs will usher in a 'nano era' of plastic pollution research.
A physical chemistry lens on environmental nanoplastics analysis challenges. Part II: detection techniques – principles, limitations and future directions
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A physical chemistry perspective examined the analytical challenges of measuring environmental nanoplastics, arguing that standard methods often miss or mischaracterize the smallest particles. The paper calls for improved analytical frameworks to better understand nanoplastic behavior and biological risks.
A critical viewpoint on current issues, limitations, and future research needs on micro- and nanoplastic studies: From the detection to the toxicological assessment.
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This critical review examines the current methods for detecting and characterizing micro- and nanoplastics in various environmental samples, as well as reported toxic effects from in vivo and in vitro studies. The authors found that while substantial effort has been made to understand microplastic behavior, the scientific community is still far from a complete understanding of how these particles behave in biological systems. The review calls for improved standardized protocols and more studies focused on uptake kinetics, accumulation, and biodistribution.
Current techniques for identifying, quantifying, and characterizing micro and nanoplastics with emphasis on strengths, limitations, and challenges
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Researchers reviewed current analytical techniques for identifying, quantifying, and characterizing micro- and nanoplastics across environmental matrices. The review highlights the strengths and limitations of methods including FTIR, Raman spectroscopy, and pyrolysis-GC/MS, and calls for standardization to improve comparability across studies.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.