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Malting barley carbon dots-mediated oxidative stress promotes insulin resistance in mice via NF-κB pathway and MAPK cascade

Journal of Nanobiotechnology 2022 16 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 35 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Xingpei Fan, Boya Zhang, Yuri Oh, Xingpei Fan, Xingpei Fan, Yuri Oh, Xingpei Fan, Lidong Yu, Xingpei Fan, Xingpei Fan, Yujie Feng, Xiangjuan Wei, Lidong Yu, Xiangjuan Wei, Yujie Feng, Hailong Hu, Ruijiao Zhu, Ruijiao Zhu, Boya Zhang, Xiangjuan Wei, Xiangjuan Wei, Yujie Feng, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Hai‐Ning Du, Yuri Oh, Hailong Hu, Hailong Hu, Yujie Feng, Yujie Feng, Yuri Oh, Hai‐Ning Du, Daqian Yang, Boya Zhang, Meimei Zhao, Ruijiao Zhu, Ruijiao Zhu, Daqian Yang, Hai‐Ning Du, Ruijiao Zhu, Ruijiao Zhu, Yujie Feng, Hai‐Ning Du, Yuri Oh, Yujie Feng, Meimei Zhao, Yuri Oh, Meimei Zhao, Meimei Zhao, Yujie Feng, Ning Gu Li Li, Ruijiao Zhu, Ruijiao Zhu, Yuri Oh, Daqian Yang, Daqian Yang, Yuri Oh, Yujie Feng, Yuri Oh, Yujie Feng, Yuri Oh, Yujie Feng, Yujie Feng, Ning Gu

Summary

Researchers found that carbon dots derived from malting barley — a type of nanoscale particle that can form in food processing — caused oxidative stress in mice that disrupted insulin function and glucose regulation, raising concerns about dietary and environmental exposure to these food-derived nanoparticles and their potential role in type 2 diabetes.

In summary, this study revealed that MBCDs promote ROS overproduction and thus induced IR, resulting in imbalance of glucose homeostasis in mice. More importantly, this study was further assessed to reveal an imperative emphasis on the reevaluation of dietary and environmental CDs exposure, and has important implications for T2DM prevention research.

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