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The potential roles of interleukin-25 in infectious diseases
Summary
This review examined the roles of interleukin-25 (IL-25) in infectious disease contexts, summarizing evidence that this cytokine bridges innate and adaptive immunity and influences responses to parasitic, bacterial, and viral pathogens. The authors identified IL-25 as a potential therapeutic target given its regulatory role in type 2 immune responses.
Interleukin-25 (IL-25), also known as IL-17E, is a recently identified cytokine of the IL-17 family. Numerous studies illustrated that the expression of IL-25 is regulated by multiple pathogens, including parasitic, viral, and bacterial infections. IL-25 has a dual function in infectious diseases. On the one hand, IL-25 activates type 2 immunity <i>via</i> the relevant cytokines, including IL-4, IL-5, and IL-13, which are associated with the development of pathogenic infection-related allergic diseases. On the other hand, IL-25 involves in the recruitment of group 2 innate lymphoid cells (ILC2) to enhanced T helper 2 (Th2) cell differentiation, which are important to the clearance of pathogens. However, the precise roles of IL-25 in infectious diseases remain largely unknown. Thus, the current review will shed light on the pivotal roles of IL-25 in infectious diseases.
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