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The future of treating pancreatic exocrine insufficiency

Nature Reviews Gastroenterology & Hepatology 2025
Matthias Löhr, Miroslav Vujasinović

Summary

Researchers identified emerging challenges for pancreatic enzyme replacement therapy in patients with exocrine insufficiency, highlighting that microplastics and nanoplastics contaminating enzyme preparations — alongside infectious agent risks — represent underappreciated future threats to treatment safety and efficacy.

Models
Human

Patients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious agents and the presence of microplastics and nanoplastics.

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