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Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop
Journal of Extracellular Biology2022
80 citations
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Score: 50
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Lucia Paolini,
Lucia Paolini,
Marta Tortajada,
Marta Tortajada,
Marta Costa,
Fabio Antenucci,
Fabio Antenucci,
Mario Barilani,
Mario Barilani,
Marta Clos‐Sansalvador,
Paolo Bergese,
Marta Clos‐Sansalvador,
Lucia Paolini,
Lucia Paolini,
Lucia Paolini,
Annalisa Radeghieri,
Annalisa Radeghieri,
André Cronemberger Andrade,
André Cronemberger Andrade,
Annalisa Radeghieri,
Tom A. P. Driedonks,
Paolo Bergese,
Paolo Bergese,
Paolo Bergese,
Tom A. P. Driedonks,
Sara Giancaterino,
Sara Giancaterino,
Stephanie M. Kronstadt,
Stephanie M. Kronstadt,
Rachel R. Mizenko,
Rachel R. Mizenko,
Muhammad Nawaz,
Xabier Osteikoetxea,
Xabier Osteikoetxea,
Carla Pereira,
Carla Pereira,
Surya Shrivastava,
Surya Shrivastava,
Anders T. Boysen,
Anders T. Boysen,
Simonides Immanuel van de Wakker,
Simonides Immanuel van de Wakker,
Martijn J. C. van Herwijnen,
Xiaoqin Wang,
Xiaoqin Wang,
Dionysios C. Watson,
Dionysios C. Watson,
Mario Gimona,
Mario Gimona,
Maria Kaparakis‐Liaskos,
Maria Kaparakis‐Liaskos,
Konstantin Konstantinov,
Konstantin Konstantinov,
Sai Kiang Lim,
Sai Kiang Lim,
Nicole Meisner‐Kober,
Nicole Meisner‐Kober,
Michiel Stork,
Michiel Stork,
Peter Nejsum,
Peter Nejsum,
Annalisa Radeghieri,
Paolo Bergese,
Annalisa Radeghieri,
Eva Rohde,
Eva Rohde,
Nicolas Touzet,
Nicolas Touzet,
Marca H. M. Wauben,
Marca H. M. Wauben,
Kenneth W. Witwer
Antonella Bongiovanni,
Antonella Bongiovanni,
Paolo Bergese,
Kenneth W. Witwer
Summary
This workshop report summarizes challenges and directions for large-scale production of extracellular vesicles, covering manufacturing, upscaling, and translation of EV-based products from discovery to clinical and industrial application.
Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, "The Extracellular Vesicle Foundry" (evFOUNDRY) and "Extracellular vesicles from a natural source for tailor-made nanomaterials" (VES4US), organized a workshop entitled "massivEVs" to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during "massivEVs", the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.