We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Understanding the interaction of micro(nano)plastics with simulated saliva, lysosomal and Gamble’s fluids and their impact on human lung epithelial A549 cells
AI summary Read the abstract
Researchers exposed micro(nano)plastics to simulated biological fluids — saliva, artificial lysosomal fluid, and Gamble's solution — for 2–80 hours and characterized the weathered particles' surface chemistry, zeta potential, and effects on human lung alveolar epithelial A549 cells, finding that biological fluid interactions alter particle properties and cellular impacts.
Abstract Micro(nano)plastics are considered an emerging threat to human health since they have potential to interact with biological systems and already been found in the human body, e.g., lungs. However, limited data is available for their behavior under biological conditions and impact on human cells, specifically alveolar epithelial cells. In this study, micro(nano)plastics weathered to various simulated biological fluids (saliva, artificial lysosomal fluids, Gamble’s solution) during 2 h to 80 h. Pristine and weathered plastic particles were characterized by their surface chemistry, zeta potentials, and elemental composition. After, various toxicological endpoints (mitochondrial membrane potential, lactate dehydrogenase, protein, and antioxidant levels) were examined through A549 lung carcinoma cells. The surface characteristics of micro(nano)plastics and the toxicological endpoints of A549 were influenced by the simulated biological weathering, specifically at high concentration of micro(nano)plastics and increasing exposure under biological conditions. The results also indicated that toxicological endpoints had strong linked with the chemistry of plastics and included the multiple processes to the response of the plastics, for instance, the cell membrane integrity and mitochondrial activity were declined with the micro(nano)plastics under saliva weathering, contrarily, their protein and antioxidant activities increased. However, different biological pathways were obtained under artificial lysosomal fluid and Gamble’s solution.
More Papers Like This
Effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles
AI summary Read the abstract
Researchers studied the effects of weathering and simulated gastric fluid exposure on cellular responses to polystyrene particles. The study suggests that environmental weathering can alter how micro- and nanoplastics interact with biological systems, with potential implications for understanding human health effects from ingested plastic particles.
Interaction of nanoplastics with simulated biological fluids and their effect on the biofilm formation
AI summary Read the abstract
Researchers investigated how nanoplastics interact with simulated biological fluids including artificial saliva and lung fluids, finding that exposure altered particle properties and that nanoplastics promoted Staphylococcus aureus biofilm formation under biological conditions.
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells.
AI summary Read the abstract
Researchers simulated how PET micro(nano)plastics are altered in phagolysosomal fluid (mimicking how lung immune cells digest particles) and found that this degradation changed the cytotoxicity profile of PET particles toward human lung epithelial cells, suggesting the body's own processing can modify plastic hazard.
A Comparative Study on the Interaction Between Protein and PET Micro/Nanoplastics: Structural and Surface Characteristics of Particles and Impacts on Lung Carcinoma Cells ( A549 ) and Staphylococcus aureus
AI summary Read the abstract
Researchers found that when proteins in the body coat tiny PET plastic particles from water bottles, the particles change in size, surface charge, and behavior. These protein-coated nanoplastics were more harmful to human lung cancer cells in lab tests than uncoated ones. The study suggests that once microplastics enter the body, they interact with proteins in ways that could increase their toxic effects on cells.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.