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The genotoxic effects of microplastics in aquatic organisms
Summary
This review examines the genotoxic effects of microplastics on aquatic organisms, synthesizing evidence across endpoints including micronuclei frequency, DNA strand breaks, and percentage of DNA in the tail (%Tail DNA), finding that genotoxicity mechanisms are closely linked to reactive oxygen species production, inflammatory responses, and interference with DNA repair pathways.
Microplastics (MPs) are anthropogenic contaminants, distributed in the entire ecosystem. However, the impact of MPs on the biota, humans, and the environment is still uncertain. Recent studies have overemphasized the occurrence, characterization, and cytotoxicity effects of MPs but deciphering the genotoxic potential of these substances is not yet clear. Thus, we provided a review to address the genotoxic effects of MPs in aquatic organisms. Several genotoxic endpoints were implicated, including the frequency of micronuclei (MN), nucleoplasmic bridge (NPB), nuclear buds (NBUD), DNA strand breaks, and the percentage of DNA in the tail (%Tail DNA). In addition, the mechanism of MPs-induced genotoxicity seems to be closely related to reactive oxygen species (ROS) production, inflammatory responses, and DNA repair interference. Further, future research was suggested to present environmentally relevant conditions. Moreover, the long-term effects of MPs should be addressed, and assessing the genotoxic effect in terrestrial ecosystems need to be taken into account. Also see: https://micro2022.sciencesconf.org/424025/document