We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Adverse Outcomes Pathways (AOPs)
AI summary Read the abstract
This review examines the concept of adverse outcome pathways (AOPs) and their application to environmental health risk assessment, including the prediction of microplastic toxicity through data mining approaches. Researchers found that AOPs can support the reduction of animal testing by identifying data gaps and guiding the development of in silico and in vitro tests for toxicity prediction.
This chapter reviews the concept of adverse outcome pathways (AOPs), basic principles for the development and assessment of AOPs, the application of AOPs to environmental health risk assessment, and future directions and challenges. The basic principles of AOP development were established through a series of workshops. Like many practices of environmental health risk assessment, AOP development relies on the application of existing information. Broader applications of AOPs to environmental health risk assessment will require determining how AOPs can more fully address the complex reality of how biological systems respond to chemicals and other environmental stressors. A data mining approach has been used to develop AOPs to help predict the toxicity of microplastics. AOPs can support the movement to reduce animal testing by helping to identify important data gaps through the weight of evidence evaluation and indicating how the development and application of specific in silico and in vitro tests can be used to help predict toxicity.
More Papers Like This
Development of AOP relevant to microplastics based on toxicity mechanisms of chemical additives using ToxCast™ and deep learning models combined approach
AI summary Read the abstract
Researchers used ToxCast high-throughput screening data and deep learning models to build adverse outcome pathway (AOP) models for common plastic additive chemicals, identifying molecular initiating events and potential health endpoints relevant to human and environmental microplastic toxicity.
Adverse outcome pathways and in vitro toxicology strategies for microplastics hazard testing
AI summary Read the abstract
Researchers proposed using the adverse outcome pathway framework to systematically assess microplastic hazards to human health, identifying mechanistic parallels with other well-characterized stressors that can guide prioritization of in vitro testing strategies for particles of different sizes, shapes, and chemistries.
The hepatotoxicity assessment of micro/nanoplastics: A preliminary study to apply the adverse outcome pathways
AI summary Read the abstract
Researchers reviewed the literature on how micro- and nanoplastics cause liver damage and organized the findings into an Adverse Outcome Pathway framework. They found that plastic particles can trigger oxidative stress, inflammation, and metabolic disruption in the liver, potentially leading to dysfunction. The study provides a structured way to understand the chain of events from plastic particle exposure to liver harm, highlighting potential health risks for humans.
Adverse outcome pathway networks of microplastic ecotoxicity to aquatic organisms: A critical review
AI summary Read the abstract
Researchers used automated text-mining combined with multi-level ecotoxicological review to construct adverse outcome pathway networks for microplastic toxicity in aquatic organisms. They mapped how microplastics cause harm from initial tissue contact through molecular disturbances to higher-level biological effects in gills, gut, liver, gonads, and brain. The study found strong evidence for early-stage toxic mechanisms but identified critical knowledge gaps in understanding downstream biological consequences.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
AI summary Read the abstract
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.