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Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells

International Journal of Nanomedicine 2023 8 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yafei Zheng, Yanjie Yang, Xu Wang, Zhenhua Song, Zhenhua Song, Yafei Zheng, Yafei Zheng, Shaoping Ji

Summary

Researchers found that zinc oxide quantum dots, despite showing no effect on cell viability, significantly disrupted intracellular metabolites and proteins in human liver cells at 20 micrograms per milliliter, affecting alcoholism and Cushing syndrome pathways.

ZnO QDs did not affect cell viability in a CCK8 assay, but disturbed the level of intracellular metabolites and proteins at 20 µg/mL. The KEGG analyses of the metabolomics and proteomics data both enriched the alcoholism and Cushing syndrome pathways. These results provide an experimental basis for future research on the safe use of nanomaterials.

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