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Fast-screening flow cytometry method for detecting nanoplastics in human peripheral blood
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Researchers developed a flow cytometry method using a fluorescent dye to detect and measure nanoplastics — plastic particles smaller than 1 micrometer — directly in human blood samples, providing one of the first approaches capable of tracking nanoplastic absorption in people and opening new avenues for studying their health effects.
Plastic pollution is a global problem. Animals and humans can ingest and inhale plastic particles, with uncertain health consequences. Nanoplastics (NPs) are particles ranging from 1 nm to 1000 nm that result from the erosion or breakage of larger plastic debris, and can be highly polydisperse in physical properties and heterogeneous in composition. Potential effects of NPs exposure may be associated with alterations in the xenobiotic metabolism, nutrients absorption, energy metabolism, cytotoxicity, and behavior. In humans, no data on NPs absorptions has been reported previously. Given that their detection relies significantly on environmental exposure, we have prospectively studied the presence of NPs in human peripheral blood (PB). Specifically, we have used fluorescence techniques and nanocytometry, together with the staining of the lipophilic dye Nile Red (NR), to demonstrate that NPs can be accurately detected using flow cytometry.•Potential effects of nanoplastics exposure.•Fluorescence techniques and nanocytometry.•Accurate detection using flow cytometry.
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Fast-screening flow cytometry method for detecting nanoplastics in human peripheral blood
AI summary Read the abstract
Researchers developed a fast-screening flow cytometry method for detecting nanoplastics in human peripheral blood, addressing the previously uncharacterized question of nanoplastic absorption in human subjects. The method enables detection of polydisperse nanoplastic particles ranging from 1 to 1000 nm in blood samples, providing a clinical screening tool to investigate human exposure to plastic particles and their potential effects on xenobiotic metabolism, nutrient absorption, and cytotoxicity.
Flow cytometry as new promising detection tool for micro and submicron plastic particles
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Researchers evaluated flow cytometry as a detection tool for micro- and nanoplastics, testing its ability to rapidly identify and count plastic particles in environmental and biological samples. Results demonstrated that flow cytometry offers a promising high-throughput approach for microplastic detection compared to more time-intensive conventional methods.
Rapid detection of nanoplastics and small microplastics by Nile-Red staining and flow cytometry
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Researchers developed a rapid method for detecting nanoplastics and small microplastics by combining Nile-Red fluorescent staining with flow cytometry. The technique can quantify plastic particles in the 0.6 to 15 micrometer range in just 90 seconds, which is hundreds of times faster than conventional spectroscopic methods. The approach showed high detection efficiency for polyethylene, polyvinylchloride, and polystyrene, offering a practical tool for environmental nanoplastic monitoring.
Flow cytometry as new promising detection tool for micro and submicron plastic particles
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Researchers evaluated flow cytometry as a tool for detecting and counting micro- and submicron plastic particles in environmental and biological samples. The method offered rapid throughput and the ability to distinguish plastic particles from biological material, but required careful optimization for complex matrices.
Quantitation of micro and nanoplastics in human blood by pyrolysis-gas chromatography–mass spectrometry
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Researchers developed and validated an improved method using pyrolysis-gas chromatography to measure specific plastic polymer types in human blood, detecting plastics in 64 out of 68 blood samples tested with a mean concentration of 268 nanograms per milliliter. Polyethylene was the most common polymer found, underscoring that microplastic and nanoplastic particles are already circulating inside the human body.
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