Paternal Inheritance Is an Important, but Overlooked, Factor Affecting the Adverse Effects of Microplastics and Nanoplastics on Subsequent Generations
Journal of Agricultural and Food Chemistry2023
4 citations
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Score: 45
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This review highlights that paternal exposure to microplastics and nanoplastics can transmit adverse effects to offspring through epigenetic inheritance, a pathway largely overlooked in multigenerational toxicity research. The authors call for greater focus on paternal transmission mechanisms to fully understand intergenerational risks.
Microplastics (MPs) and nanoplastics (NPs) are widely detected in food and the human environment. More studies have begun to pay attention to the influence of MPs and NPs on genetics; in particular, exposure of paternal generation to MPs and NPs on epigenetic inheritance and the offspring of animal models have attracted considerable interest. In this Viewpoint, we mainly discuss the suggestion that reproductive genetic changes in the male parent have the potential to be transferred to the offspring and illustrate how MPs and NPs in the father tissues are distributed in later generations. We provide a systematic understanding of the potential health hazards of paternal exposure to MPs and NPs to subsequent generations and put forth recommendations about the epigenetic effects for future research on public health and food safety.