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Physicochemical and antibacterial properties of Graphene Oxide-Silver/Graphene Oxide/Chitosan composite wound dressing
Summary
Researchers developed a graphene oxide-silver/graphene oxide/chitosan composite wound dressing and found that incorporating 4 wt% graphene oxide improved wet-state tensile strength by 214%, while the composite demonstrated non-cytotoxic properties and antibacterial activity, making it a promising candidate for clinical wound care applications.
Abstract Graphene oxide was prepared by the modified Hummers method and ultrasonic treatment, ammoniacal silver solution and glucose were added into graphene oxide suspension to prepare graphene oxide-silver (GO-Ag) nanoparticles. And then the achieved GO-Ag nanoparticles were incorporated into chitosan and graphene oxide to prepare graphene oxide-silver/graphene oxide /chitosan(GO-Ag/GO/CS) composites. The structure and properties of GO-Ag/GO/CS composite have been investigated by XRD, IR, TG, Tensile test, cytotoxicity test and antibacterial test. XRD and IR analysis indicated that GO-Ag was successfully compounded with graphene oxide and chitosan, the structure of GO-Ag was unchanged after being incorporation. Tensile test showed that the incorporation of graphene oxide into chitosan matrix can effectively improve the tensile strength of GO-Ag/GO/CS composite, especially the wet-state tensile strength. When incorporated of 4wt% GO into chitosan matrix, the wet-state tensile strengths of GO-Ag/GO/CS were improved by 214.3% compared with chitosan matrix. Thermogravimetric analysis indicated that the incorporation of graphene oxide has a slight effect on the thermal stability of CS. The results of cytotoxicity test showed that the cytotoxicity levels of GO-Ag/GO/CS composites were all in the range of non-cytotoxic when the dosages of GO-Ag were changing from 3.0 mg to 6.0 mg, which satisfied the safety standards of biomaterials. The bacteriostatic rate of GO-Ag/GO/CS-5 group (contain 5mg GO-Ag) against Staphylococcus aureus can reach 98.31%, showing excellent bacteriostatic effect, which could be used for further experimental study.
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