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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Marine & Wildlife Policy & Risk Sign in to save

Combined effect of microplastic, salinomycin and heating on Unio tumidus

Environmental Toxicology and Pharmacology 2023 62 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Оksana Stoliar, Viktoria Martyniuk, Viktoria Martyniuk, Viktoria Martyniuk, Caterina Faggio Viktoria Martyniuk, Viktoria Martyniuk, Viktoria Martyniuk, Kateryna Yunko, Tetiana Matskiv, Tetiana Matskiv, Viktoria Martyniuk, Vira Khoma, Tetiana Matskiv, Tetiana Matskiv, Оksana Stoliar, Caterina Faggio Caterina Faggio Caterina Faggio Viktoria Martyniuk, Vira Khoma, Viktoria Martyniuk, Kateryna Yunko, Kateryna Yunko, Lesya Gnatyshyna, Kateryna Yunko, Kateryna Yunko, Tetiana Matskiv, Viktoria Martyniuk, Vira Khoma, Viktoria Martyniuk, Tetiana Matskiv, Tetiana Matskiv, Caterina Faggio Vira Khoma, Vira Khoma, Lesya Gnatyshyna, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Kateryna Yunko, Kateryna Yunko, Оksana Stoliar, Tetiana Matskiv, Tetiana Matskiv, Vira Khoma, Vira Khoma, Vira Khoma, Vira Khoma, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Vira Khoma, Lesya Gnatyshyna, Caterina Faggio Caterina Faggio Lesya Gnatyshyna, Caterina Faggio Caterina Faggio Lesya Gnatyshyna, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Tetiana Matskiv, Caterina Faggio Caterina Faggio Caterina Faggio Оksana Stoliar, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Lesya Gnatyshyna, Lesya Gnatyshyna, Vira Khoma, Оksana Stoliar, Caterina Faggio Caterina Faggio Оksana Stoliar, Caterina Faggio Lesya Gnatyshyna, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Оksana Stoliar, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Оksana Stoliar, Оksana Stoliar, Lesya Gnatyshyna, Оksana Stoliar, Оksana Stoliar, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Оksana Stoliar, Оksana Stoliar, Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio Caterina Faggio

Summary

Researchers studied how microplastics interact with a common veterinary antibiotic and elevated water temperatures to affect freshwater mussels. While microplastics and the antibiotic alone caused mild stress, the combination under warmer conditions dampened the mussels' protective enzyme responses rather than amplifying them. This finding highlights that the effects of microplastics cannot be studied in isolation, as real-world conditions involve multiple stressors that interact in complex and sometimes unexpected ways.

Body Systems
Digestive

Microplastic (MP) and heating (T) suspected to modulate biological effects of aquatic contaminants. Salinomycin (Sal) is veterinary antibiotic and anticancer agent. The goal of this study was to examine the multistress effect of MP, Sal and T on the bioindicator bivalve mollusc. The Unio tumidus were treated with MP (1 mg L<sup>-1</sup>), Sal (0.6 µg L<sup>-1</sup>), their combination under 18° C (Mix) and 25° C (MixT) for 14 days. The digestive glands were analyzed. MP and Sal did not cause changes of Mn- and Cu,Zn-SOD, lipid peroxidation and Cyp-450-depended EROD levels, whereas catalase, GST and protein carbonyls (Sal-group) increased compared to control. In the Mix-group, enzymes, particularly EROD and GST (by 34% and 115% respectively) were up-regulated. However, in the MixT-group, they were corresponding to control or lesser (EROD, catalase). Our findings emphasize the need to take into account multistress interactions in the MP environmental risk assessment.

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