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The toxic effect of bisphenol AF and nanoplastic coexposure in parental and offspring generation zebrafish
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Researchers exposed adult zebrafish to bisphenol AF and nanoplastics for 45 days and examined effects across multiple generations of offspring. The study found that both single BPAF exposure and combined BPAF-nanoplastic exposure decreased egg production and locomotor behavior in parents, and negatively affected hatching rates, mortality, body length, and behavior in offspring, indicating transgenerational toxic effects.
Microplastics (MPs) and bisphenol AF (BPAF) are two environmental pollutants that usually coexist in the natural environment. Studies of MPs or BPAF have gradually increased in recent years, but few studies have focused on the combination toxic effects. In this study, the subchronic model of adult zebrafish was exposed to 1 mg/L nanolevel microplastics and 200 μg/L BPAF for 45 days; the parental zebrafish were spawning every 3 days during exposure, and the effects of continuous poisoning were examined on the offspring after 1-9 spawns. The results showed that single BPAF exposure or BPAF and nanoplastic coexposure can both decrease the number of eggs laid and the locomotor behavior of parental zebrafish and impact the hatching rate, mortality, body length and locomotor behavior of offspring zebrafish, especially in 7-9 spawn. BPAF were accumulated in parental zebrafish intestinal in 334.62 ng/g in BPAF group and 594.52 ng/g in nm+BPAF group, and accumulated in whole offspring zebrafish for 281.6 ng/g in BPAF group and 321.46 ng/g in nm+BPAF group. Neurodevelopmental, inflammation, apoptosis and oxidative stress-related genes were also significantly increased after 7-9 spawn. In addition, the exacerbated accumulation in the BPAF+nm group in parental and offspring zebrafish may be the reason for the accelerated toxic effect in the present research. In this study, we investigated the combined effects of nanoplastics and BPAF on parental and offspring zebrafish in the aquatic environment to identify the accumulative toxic effects and provide new experimental support for assessing the effects of coexposure on aquatic organisms.
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When adult zebrafish were exposed to combinations of microplastics with bisphenol A (BPA) or bisphenol S (BPS), the reproductive damage was worse than from any single pollutant alone, and the effects carried over to their offspring. The BPA-microplastic combination primarily affected brain function, while BPS-microplastic exposure mainly disrupted visual development in the next generation. This study highlights that microplastics can amplify the harmful effects of common plastic chemicals, with consequences that extend to future generations.
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This review examines multigenerational effects of nanomaterials, including nanoplastics, studied in non-mammalian models such as nematodes, water fleas, and zebrafish. Researchers found common effects across generations including altered life-history traits, oxidative stress, and transfer of nanomaterials to offspring. The study highlights that co-exposure to nanoplastics alongside other pollutants can produce either synergistic toxicity or alleviating effects depending on the combination.
Transgenerational effects of Nanoplastics and bisphenol A on Zebrafish lipid metabolism: Disruption of the gut Microbiota-liver axis via mTOR pathway
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Researchers exposed zebrafish to nanoplastics and bisphenol A, a chemical commonly found in plastics, and tracked the effects across three generations. They found that the combined exposure disrupted fat metabolism, damaged gut bacteria and liver function in the first generation, and these metabolic problems were passed down to offspring that were never directly exposed. The study suggests that nanoplastic and chemical co-exposure may cause health effects that persist across multiple generations.
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This zebrafish study found that combined exposure to polystyrene microplastics and arsenic caused more severe reproductive damage than either pollutant alone, including abnormal egg development and disrupted hormone levels. The toxic effects were passed down to the next generation, even though offspring were not directly exposed. Since microplastics can carry arsenic and other heavy metals in the environment, their combined effects on fertility may be worse than studies of individual pollutants suggest.
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