0
Article Tier 2 Policy & Risk Sign in to save

Dysregulation of Cellular Immune Functions on Gastric Administration to Mixtures of Polyethlene Microplastics and Metallic Lead in Mice

AI summary Read the abstract

This Korean study examined how mixtures of polyethylene microplastics and lead affect the immune function of mice. Gastric administration of the combined pollutants dysregulated cellular immune responses. The findings indicate that microplastics can interact with heavy metals to cause combined health effects, including immune system disruption, which is particularly concerning given human exposure to both contaminants.

Models

I. 서 론 우리 사회와 일상생활에서 존재하는 화학물질

More Papers Like This

Article Tier 2

Immunodysregulatory potentials of polyethylene or polytetrafluorethylene microplastics to mice subacutely exposed via intragastric intubation

AI summary Read the abstract

Researchers found that subacute oral exposure to polyethylene and polytetrafluoroethylene microplastics caused immune dysregulation in mice, with effects varying by particle size and polymer type, demonstrating that ingested microplastics can disrupt immune function.

Article Tier 2

Size-specific effects of microplastics and lead on zebrafish

AI summary Read the abstract

Researchers studied how microplastics of different sizes interact with lead in zebrafish and found that the combination damaged gut barrier function and triggered liver inflammation more than either pollutant alone. The smallest microplastics paired with lead caused the most significant disruption to gut bacteria diversity. These findings highlight that microplastics can worsen the toxic effects of heavy metals in living organisms.

Article Tier 2

Repeated exposure to polyethylene microplastic mixtures containing PFAS and bisphenols activates THP-1 macrophages with inflammatory features

AI summary Read the abstract

Researchers exposed THP-1 macrophages repeatedly to polyethylene microplastics combined with PFAS and bisphenol additives to more accurately simulate real-world human contamination. The study found that repeated exposure activated macrophages with inflammatory features, suggesting that the combination of microplastics and their chemical additives may trigger immune responses in human cells.

Article Tier 2

Toxicity of co-exposure of microplastics and lead in African catfish (Clarias gariepinus)

AI summary Read the abstract

Researchers exposed African catfish to lead, microplastics, and a combination of both for 15 days and found that the combined exposure was more harmful than either pollutant alone. The mixture caused the greatest damage to blood cells, triggered stronger inflammatory responses, and disrupted the fish's antioxidant defenses. Since microplastics can carry heavy metals like lead on their surfaces, this study shows how microplastics may amplify the toxic effects of other pollutants in freshwater fish that people eat.

Article Tier 2

Effect of micro- and nanoplastics as food contaminants on the immune system

AI summary Read the abstract

This review synthesized research on how microplastic and nanoplastic exposure affects immune system function, finding evidence across multiple studies that these particles can modulate immune responses and trigger inflammatory pathways in exposed organisms. The authors highlight immune disruption as an emerging health concern from micro- and nanoplastic contamination.

Research digests by email

When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.

Email me about

Share this paper